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Design of siRNA Therapeutics from the Molecular Scale

Delivery of RNAi-Based Oligonucleotides by Electropermeabilization

Centre National de la Recherche Scientifique (CNRS), Institut de Pharmacologie et de Biologie Structurale (IPBS) BP 64182, 205 route de Narbonne, Toulouse F-31077, France
Université Paul Sabatier de Toulouse, IPBS, Toulouse F-31077, France
Author to whom correspondence should be addressed.
Pharmaceuticals 2013, 6(4), 510-521;
Received: 31 December 2012 / Revised: 19 March 2013 / Accepted: 27 March 2013 / Published: 10 April 2013
(This article belongs to the Special Issue RNAi-Based Therapeutics)
For more than a decade, understanding of RNA interference (RNAi) has been a growing field of interest. The potent gene silencing ability that small oligonucleotides have offers new perspectives for cancer therapeutics. One of the present limits is that many biological barriers exist for their efficient delivery into target cells or tissues. Electropermeabilization (EP) is one of the physical methods successfully used to transfer small oligonucleotides into cells or tissues. EP consists in the direct application of calibrated electric pulses to cells or tissues that transiently permeabilize the plasma membranes, allowing efficient in vitro and in vivo. cytoplasmic delivery of exogenous molecules. The present review reports on the type of therapeutic RNAi-based oligonucleotides that can be electrotransferred, the mechanism(s) of their electrotransfer and the technical settings for pre-clinical purposes. View Full-Text
Keywords: electroporation; siRNA; miRNA; LNA; siLNA electroporation; siRNA; miRNA; LNA; siLNA
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MDPI and ACS Style

Chabot, S.; Pelofy, S.; Teissié, J.; Golzio, M. Delivery of RNAi-Based Oligonucleotides by Electropermeabilization. Pharmaceuticals 2013, 6, 510-521.

AMA Style

Chabot S, Pelofy S, Teissié J, Golzio M. Delivery of RNAi-Based Oligonucleotides by Electropermeabilization. Pharmaceuticals. 2013; 6(4):510-521.

Chicago/Turabian Style

Chabot, Sophie, Sandrine Pelofy, Justin Teissié, and Muriel Golzio. 2013. "Delivery of RNAi-Based Oligonucleotides by Electropermeabilization" Pharmaceuticals 6, no. 4: 510-521.

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