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Volume 17
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Review

Therapeutic Prospects of Mesenchymal Stem Cell and Their Derived Exosomes in the Regulation of the Gut Microbiota in Inflammatory Bowel Disease

by
Yaru Qiao
1,2,†,
Xiaohua Tang
3,†,
Ziyue Liu
1,
Dickson Kofi Wiredu Ocansey
1,4,
Mengjiao Zhou
1,
Anquan Shang
2 and
Fei Mao
1,2,*
1
Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang 212013, China
2
Department of Laboratory Medicine, Lianyungang Clinical College, Jiangsu University, Lianyungang 222006, China
3
The People’s Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Zhenjiang 212300, China
4
Department of Medical Laboratory Science, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast CC0959347, Ghana
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Pharmaceuticals 2024, 17(5), 607; https://doi.org/10.3390/ph17050607
Submission received: 4 April 2024 / Revised: 5 May 2024 / Accepted: 6 May 2024 / Published: 9 May 2024
(This article belongs to the Special Issue Stem Cells and Organoids as Tools for Drug Development)
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Abstract

Mesenchymal stem cells (MSCs) have shown great potential in the treatment of several inflammatory diseases due to their immunomodulatory ability, which is mediated by exosomes secreted by MSCs (MSC-Exs). The incidence of inflammatory bowel disease (IBD) is increasing globally, but there is currently no long-term effective treatment. As an emerging therapy, MSC-Exs have proven to be effective in alleviating IBD experimentally, and the specific mechanism continues to be explored. The gut microbiota plays an important role in the occurrence and development of IBD, and MSCs and MSC-Exs can effectively regulate gut microbiota in animal models of IBD, but the mechanism involved and whether the outcome can relieve the characteristic dysbiosis necessary to alleviate IBD still needs to be studied. This review provides current evidence on the effective modulation of the gut microbiota by MSC-Exs, offering a basis for further research on the pathogenic mechanism of IBD and MSC-Ex treatments through the improvement of gut microbiota.
Keywords: mesenchymal stem cells; exosomes; inflammatory bowel disease; gut microbiota; therapy mesenchymal stem cells; exosomes; inflammatory bowel disease; gut microbiota; therapy

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MDPI and ACS Style

Qiao, Y.; Tang, X.; Liu, Z.; Ocansey, D.K.W.; Zhou, M.; Shang, A.; Mao, F. Therapeutic Prospects of Mesenchymal Stem Cell and Their Derived Exosomes in the Regulation of the Gut Microbiota in Inflammatory Bowel Disease. Pharmaceuticals 2024, 17, 607. https://doi.org/10.3390/ph17050607

AMA Style

Qiao Y, Tang X, Liu Z, Ocansey DKW, Zhou M, Shang A, Mao F. Therapeutic Prospects of Mesenchymal Stem Cell and Their Derived Exosomes in the Regulation of the Gut Microbiota in Inflammatory Bowel Disease. Pharmaceuticals. 2024; 17(5):607. https://doi.org/10.3390/ph17050607

Chicago/Turabian Style

Qiao, Yaru, Xiaohua Tang, Ziyue Liu, Dickson Kofi Wiredu Ocansey, Mengjiao Zhou, Anquan Shang, and Fei Mao. 2024. "Therapeutic Prospects of Mesenchymal Stem Cell and Their Derived Exosomes in the Regulation of the Gut Microbiota in Inflammatory Bowel Disease" Pharmaceuticals 17, no. 5: 607. https://doi.org/10.3390/ph17050607

APA Style

Qiao, Y., Tang, X., Liu, Z., Ocansey, D. K. W., Zhou, M., Shang, A., & Mao, F. (2024). Therapeutic Prospects of Mesenchymal Stem Cell and Their Derived Exosomes in the Regulation of the Gut Microbiota in Inflammatory Bowel Disease. Pharmaceuticals, 17(5), 607. https://doi.org/10.3390/ph17050607

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