Sensitization of Antibiotic-Resistant Gram-Negative Bacteria to Photodynamic Therapy via Perfluorocarbon Nanoemulsion
Abstract
:1. Introduction
2. Results and Discussion
2.1. Preparation of Ce6@FDC
2.2. Oxygen Loading and Releasing Behavior of Ce6@FDC
2.3. Enhanced Singlet Oxygen Generation
2.4. Facilitated Bacteria Association of Ce6@FDC
2.5. Photodynamic Bactericidal Performance against Antibiotic-Resistant Gram-Negative Bacteria
2.6. Potent Biofilm Ablation Ability In Vitro
3. Materials and Methods
3.1. Materials
3.2. Preparation of Ce6@FDC Nanoemulsion
3.3. Characterization
3.4. Oxygen Loading and Releasing of Ce6@FDC
3.5. Light-Triggered 1O2-Generation Ability of Ce6@FDC + O2
3.6. Bacterial Association of Ce6@FDC
3.7. In Vitro Photodynamic Antibacterial Activity
3.8. In Vitro Ablation Capacity of Bacterial Biofilm
3.9. Statistics Analysis
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Niu, P.; Dai, J.; Wang, Z.; Wang, Y.; Feng, D.; Li, Y.; Miao, W. Sensitization of Antibiotic-Resistant Gram-Negative Bacteria to Photodynamic Therapy via Perfluorocarbon Nanoemulsion. Pharmaceuticals 2022, 15, 156. https://doi.org/10.3390/ph15020156
Niu P, Dai J, Wang Z, Wang Y, Feng D, Li Y, Miao W. Sensitization of Antibiotic-Resistant Gram-Negative Bacteria to Photodynamic Therapy via Perfluorocarbon Nanoemulsion. Pharmaceuticals. 2022; 15(2):156. https://doi.org/10.3390/ph15020156
Chicago/Turabian StyleNiu, Peiyuan, Jialing Dai, Zeyu Wang, Yueying Wang, Duxiang Feng, Yuanyuan Li, and Wenjun Miao. 2022. "Sensitization of Antibiotic-Resistant Gram-Negative Bacteria to Photodynamic Therapy via Perfluorocarbon Nanoemulsion" Pharmaceuticals 15, no. 2: 156. https://doi.org/10.3390/ph15020156