Next Article in Journal
Monocrotaline-Induced Pulmonary Arterial Hypertension and Bosentan Treatment in Rats: Focus on Plasma and Erythrocyte Parameters
Previous Article in Journal
Polyphenols, Saponins and Phytosterols in Lentils and Their Health Benefits: An Overview
 
 
Article
Peer-Review Record

Reservoir-Style Polymeric Drug Delivery Systems: Empirical and Predictive Models for Implant Design

Pharmaceuticals 2022, 15(10), 1226; https://doi.org/10.3390/ph15101226
by Linying Li 1, Chanhwa Lee 2, Daniela F. Cruz 1, Sai Archana Krovi 1, Michael G. Hudgens 2, Mackenzie L. Cottrell 3 and Leah M. Johnson 1,*
Reviewer 1:
Reviewer 2: Anonymous
Pharmaceuticals 2022, 15(10), 1226; https://doi.org/10.3390/ph15101226
Submission received: 17 August 2022 / Revised: 21 September 2022 / Accepted: 24 September 2022 / Published: 3 October 2022
(This article belongs to the Section Biopharmaceuticals)

Round 1

Reviewer 1 Report

The manuscript concerns the implication of empirical model to evaluate the drug release from subcutaneous implants in experiments in vitro. The empirical models based on the established properties of the well-knonw drugs may be of interest to enhcnase the modern testing protocols in the development of novel drug formulations. I believe, experimental studies can not be completely replaced by empirical models, however, can be strongly supported by them. The study is well designed, the methods are adequate, and the conclusions are well supported by the reported results. The manuscript is suitable for publication in Pharmaceuticals after very minor revision. 

In the experimental section, I would like the authors to concretize how the cumulative release was calculated in experiments in vitro, and how the concentration of the released drugs was measured in the PBS?

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report


Comments for author File: Comments.pdf

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Back to TopTop