Next Article in Journal
A Meta-Analysis of the Analgesic Efficacy of Single-Doses of Ibuprofen Compared to Traditional Non-Opioid Analgesics Following Third Molar Surgery
Next Article in Special Issue
In Vitro and In Vivo Gastrointestinal Survival of Non-Encapsulated and Microencapsulated Salmonella Bacteriophages: Implications for Bacteriophage Therapy in Poultry
Previous Article in Journal
Feasibility of Developing Radiotracers for MDM2: Synthesis and Preliminary Evaluation of an 18F-Labeled Analogue of the MDM2 Inhibitor SP-141
Previous Article in Special Issue
Luminescent Phage-Based Detection of Klebsiella pneumoniae: From Engineering to Diagnostics
Review

Formulations for Bacteriophage Therapy and the Potential Uses of Immobilization

Fixed Phage Ltd., Glasgow G20 0SP, UK
*
Author to whom correspondence should be addressed.
Academic Editors: Paul Hyman, Christine Schneider and Bryan Gibb
Pharmaceuticals 2021, 14(4), 359; https://doi.org/10.3390/ph14040359
Received: 20 February 2021 / Revised: 9 April 2021 / Accepted: 10 April 2021 / Published: 13 April 2021
(This article belongs to the Special Issue Bacteriophages as Therapeutic Delivery Vehicles)
The emergence of antibiotic-resistant pathogens is becoming increasingly problematic in the treatment of bacterial diseases. This has led to bacteriophages receiving increased attention as an alternative form of treatment. Phages are effective at targeting and killing bacterial strains of interest and have yielded encouraging results when administered as part of a tailored treatment to severely ill patients as a last resort. Despite this, success in clinical trials has not always been as forthcoming, with several high-profile trials failing to demonstrate the efficacy of phage preparations in curing diseases of interest. Whilst this may be in part due to reasons surrounding poor phage selection and a lack of understanding of the underlying disease, there is growing consensus that future success in clinical trials will depend on effective delivery of phage therapeutics to the area of infection. This can be achieved using bacteriophage formulations instead of purely liquid preparations. Several encapsulation-based strategies can be applied to produce phage formulations and encouraging results have been observed with respect to efficacy as well as long term phage stability. Immobilization-based approaches have generally been neglected for the production of phage therapeutics but could also offer a viable alternative. View Full-Text
Keywords: phage therapy; phage formulations; immobilization; encapsulation; therapeutic delivery phage therapy; phage formulations; immobilization; encapsulation; therapeutic delivery
MDPI and ACS Style

Rosner, D.; Clark, J. Formulations for Bacteriophage Therapy and the Potential Uses of Immobilization. Pharmaceuticals 2021, 14, 359. https://doi.org/10.3390/ph14040359

AMA Style

Rosner D, Clark J. Formulations for Bacteriophage Therapy and the Potential Uses of Immobilization. Pharmaceuticals. 2021; 14(4):359. https://doi.org/10.3390/ph14040359

Chicago/Turabian Style

Rosner, Daniel; Clark, Jason. 2021. "Formulations for Bacteriophage Therapy and the Potential Uses of Immobilization" Pharmaceuticals 14, no. 4: 359. https://doi.org/10.3390/ph14040359

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop