Next Article in Journal
Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing
Next Article in Special Issue
An Evaluation of the Potential of Essential Oils against SARS-CoV-2 from In Silico Studies through the Systematic Review Using a Chemometric Approach
Previous Article in Journal
Model-Based Approach for Designing an Efficient Bioequivalence Study for Highly Variable Drugs
Previous Article in Special Issue
Elucidating the Effects of Curcumin against Influenza Using In Silico and In Vitro Approaches
Review

Antiviral Activities of Andrographolide and Its Derivatives: Mechanism of Action and Delivery System

1
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Bulaksumur, Yogyakarta 55281, Indonesia
2
Research Center for Biotechnology, Research Organization for Life Sciences, National Research and Innovation Agency (BRIN), Jalan Raya Jakarta-Bogor KM. 46, Cibinong 16911, Indonesia
3
Research Center for Biology, Research Organization for Life Sciences, National Research and Innovation Agency (BRIN), Jalan Raya Jakarta-Bogor KM. 46, Cibinong 16911, Indonesia
*
Authors to whom correspondence should be addressed.
Academic Editor: Daniela De Vita
Pharmaceuticals 2021, 14(11), 1102; https://doi.org/10.3390/ph14111102
Received: 4 October 2021 / Revised: 23 October 2021 / Accepted: 25 October 2021 / Published: 28 October 2021
(This article belongs to the Special Issue Antiviral Compounds in Medicinal Plants)
Andrographispaniculata (Burm.f.) Nees has been used as a traditional medicine in Asian countries, especially China, India, Vietnam, Malaysia, and Indonesia. This herbaceous plant extract contains active compounds with multiple biological activities against various diseases, including the flu, colds, fever, diabetes, hypertension, and cancer. Several isolated compounds from A. paniculata, such as andrographolide and its analogs, have attracted much interest for their potential treatment against several virus infections, including SARS-CoV-2. The mechanisms of action in inhibiting viral infections can be categorized into several types, including regulating the viral entry stage, gene replication, and the formation of mature functional proteins. The efficacy of andrographolide as an antiviral candidate was further investigated since the phytoconstituents of A. paniculata exhibit various physicochemical characteristics, including low solubility and low bioavailability. A discussion on the delivery systems of these active compounds could accelerate their development for commercial applications as antiviral drugs. This study critically reviewed the current antiviral development based on andrographolide and its derivative compounds, especially on their mechanism of action as antiviral drugs and drug delivery systems. View Full-Text
Keywords: Andrographis paniculata; andrographolide; antivirals; mechanism of action; drug delivery system Andrographis paniculata; andrographolide; antivirals; mechanism of action; drug delivery system
Show Figures

Figure 1

MDPI and ACS Style

Adiguna, S.P.; Panggabean, J.A.; Atikana, A.; Untari, F.; Izzati, F.; Bayu, A.; Rosyidah, A.; Rahmawati, S.I.; Putra, M.Y. Antiviral Activities of Andrographolide and Its Derivatives: Mechanism of Action and Delivery System. Pharmaceuticals 2021, 14, 1102. https://doi.org/10.3390/ph14111102

AMA Style

Adiguna SP, Panggabean JA, Atikana A, Untari F, Izzati F, Bayu A, Rosyidah A, Rahmawati SI, Putra MY. Antiviral Activities of Andrographolide and Its Derivatives: Mechanism of Action and Delivery System. Pharmaceuticals. 2021; 14(11):1102. https://doi.org/10.3390/ph14111102

Chicago/Turabian Style

Adiguna, Sya’ban P., Jonathan A. Panggabean, Akhirta Atikana, Febriana Untari, Fauzia Izzati, Asep Bayu, A’liyatur Rosyidah, Siti I. Rahmawati, and Masteria Y. Putra. 2021. "Antiviral Activities of Andrographolide and Its Derivatives: Mechanism of Action and Delivery System" Pharmaceuticals 14, no. 11: 1102. https://doi.org/10.3390/ph14111102

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop