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Open AccessReview

Emerging Therapeutic Modalities against COVID-19

1
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA
2
Department of Chemistry, Wesleyan University, Middletown, CT 06459, USA
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(8), 188; https://doi.org/10.3390/ph13080188
Received: 13 July 2020 / Revised: 30 July 2020 / Accepted: 4 August 2020 / Published: 8 August 2020
(This article belongs to the Special Issue COVID-19 in Pharmaceuticals)
The novel SARS-CoV-2 virus has quickly spread worldwide, bringing the whole world as well as the economy to a standstill. As the world is struggling to minimize the transmission of this devastating disease, several strategies are being actively deployed to develop therapeutic interventions. Pharmaceutical companies and academic researchers are relentlessly working to investigate experimental, repurposed or FDA-approved drugs on a compassionate basis and novel biologics for SARS-CoV-2 prophylaxis and treatment. Presently, a tremendous surge of COVID-19 clinical trials are advancing through different stages. Among currently registered clinical efforts, ~86% are centered on testing small molecules or antibodies either alone or in combination with immunomodulators. The rest ~14% of clinical efforts are aimed at evaluating vaccines and convalescent plasma-based therapies to mitigate the disease's symptoms. This review provides a comprehensive overview of current therapeutic modalities being evaluated against SARS-CoV-2 virus in clinical trials. View Full-Text
Keywords: SARS-CoV-2; coronavirus; COVID-19; remdesivir; antiviral; vaccine SARS-CoV-2; coronavirus; COVID-19; remdesivir; antiviral; vaccine
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MDPI and ACS Style

Malik, S.; Gupta, A.; Zhong, X.; Rasmussen, T.P.; Manautou, J.E.; Bahal, R. Emerging Therapeutic Modalities against COVID-19. Pharmaceuticals 2020, 13, 188.

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