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The Expanding Role of MT1-MMP in Cancer Progression

1
Department of Chemistry & Biochemistry and the Center for Molecular Biology & Biotechnology, Florida Atlantic University, Jupiter, FL 33458 USA
2
Department of Chemistry, The Scripps Research Institute/Scripps Florida, Jupiter, FL 33458, USA
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2019, 12(2), 77; https://doi.org/10.3390/ph12020077
Received: 1 May 2019 / Revised: 16 May 2019 / Accepted: 18 May 2019 / Published: 20 May 2019
(This article belongs to the Special Issue Matrix Metalloproteinases)
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Abstract

For over 20 years, membrane type 1 matrix metalloproteinase (MT1-MMP) has been recognized as a key component in cancer progression. Initially, the primary roles assigned to MT1-MMP were the activation of proMMP-2 and degradation of fibrillar collagen. Proteomics has revealed a great array of MT1-MMP substrates, and MT1-MMP selective inhibitors have allowed for a more complete mapping of MT1-MMP biological functions. MT1-MMP has extensive sheddase activities, is both a positive and negative regulator of angiogenesis, can act intracellularly and as a transcription factor, and modulates immune responses. We presently examine the multi-faceted role of MT1-MMP in cancer, with a consideration of how the diversity of MT1-MMP behaviors impacts the application of MT1-MMP inhibitors. View Full-Text
Keywords: matrix metalloproteinase; extracellular matrix; cancer progression; immunosuppression; signal transduction; collagenolysis matrix metalloproteinase; extracellular matrix; cancer progression; immunosuppression; signal transduction; collagenolysis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Knapinska, A.M.; Fields, G.B. The Expanding Role of MT1-MMP in Cancer Progression. Pharmaceuticals 2019, 12, 77.

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