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The Expanding Role of MT1-MMP in Cancer Progression

Department of Chemistry & Biochemistry and the Center for Molecular Biology & Biotechnology, Florida Atlantic University, Jupiter, FL 33458 USA
Department of Chemistry, The Scripps Research Institute/Scripps Florida, Jupiter, FL 33458, USA
Author to whom correspondence should be addressed.
Pharmaceuticals 2019, 12(2), 77;
Received: 1 May 2019 / Revised: 16 May 2019 / Accepted: 18 May 2019 / Published: 20 May 2019
(This article belongs to the Special Issue Matrix Metalloproteinases)
PDF [894 KB, uploaded 20 May 2019]


For over 20 years, membrane type 1 matrix metalloproteinase (MT1-MMP) has been recognized as a key component in cancer progression. Initially, the primary roles assigned to MT1-MMP were the activation of proMMP-2 and degradation of fibrillar collagen. Proteomics has revealed a great array of MT1-MMP substrates, and MT1-MMP selective inhibitors have allowed for a more complete mapping of MT1-MMP biological functions. MT1-MMP has extensive sheddase activities, is both a positive and negative regulator of angiogenesis, can act intracellularly and as a transcription factor, and modulates immune responses. We presently examine the multi-faceted role of MT1-MMP in cancer, with a consideration of how the diversity of MT1-MMP behaviors impacts the application of MT1-MMP inhibitors. View Full-Text
Keywords: matrix metalloproteinase; extracellular matrix; cancer progression; immunosuppression; signal transduction; collagenolysis matrix metalloproteinase; extracellular matrix; cancer progression; immunosuppression; signal transduction; collagenolysis

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Knapinska, A.M.; Fields, G.B. The Expanding Role of MT1-MMP in Cancer Progression. Pharmaceuticals 2019, 12, 77.

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