Protective Effect of Cashew Gum (Anacardium occidentale L.) on 5-Fluorouracil-Induced Intestinal Mucositis
AbstractIntestinal mucositis is a common complication associated with 5-fluorouracil (5-FU), a chemotherapeutic agent used for cancer treatment. Cashew gum (CG) has been reported as a potent anti-inflammatory agent. In the present study, we aimed to evaluate the effect of CG extracted from the exudate of Anacardium occidentale L. on experimental intestinal mucositis induced by 5-FU. Swiss mice were randomly divided into seven groups: Saline, 5-FU, CG 30, CG 60, CG 90, Celecoxib (CLX), and CLX + CG 90 groups. The weight of mice was measured daily. After treatment, the animals were euthanized and segments of the small intestine were collected to evaluate histopathological alterations (morphometric analysis), levels of malondialdehyde (MDA), myeloperoxidase (MPO), and glutathione (GSH), and immunohistochemical analysis of interleukin 1 beta (IL-1β) and cyclooxygenase-2 (COX-2). 5-FU induced intense weight loss and reduction in villus height compared to the saline group. CG 90 prevented 5-FU-induced histopathological changes and decreased oxidative stress through decrease of MDA levels and increase of GSH concentration. CG attenuated inflammatory process by decreasing MPO activity, intestinal mastocytosis, and COX-2 expression. Our findings suggest that CG at a concentration of 90 mg/kg reverses the effects of 5-FU-induced intestinal mucositis.
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de Miranda, J.A.L.; Barreto, J.E.F.; Martins, D.S.; de Souza Pimentel, P.V.; da Silva Costa, D.V.; e Silva, R.R.; de Souza, L.K.M.; de Lima, C.N.C.; Rocha, J.A.; de Freitas, A.P.F.; da Silva, D.A.; Scafuri, A.G.; de Leitão, R.F.C.; de Castro Brito, G.A.; Medeiros, J.V.R.; Cerqueira, G.S. Protective Effect of Cashew Gum (Anacardium occidentale L.) on 5-Fluorouracil-Induced Intestinal Mucositis. Pharmaceuticals 2019, 12, 51.
de Miranda JAL, Barreto JEF, Martins DS, de Souza Pimentel PV, da Silva Costa DV, e Silva RR, de Souza LKM, de Lima CNC, Rocha JA, de Freitas APF, da Silva DA, Scafuri AG, de Leitão RFC, de Castro Brito GA, Medeiros JVR, Cerqueira GS. Protective Effect of Cashew Gum (Anacardium occidentale L.) on 5-Fluorouracil-Induced Intestinal Mucositis. Pharmaceuticals. 2019; 12(2):51.Chicago/Turabian Style
de Miranda, João Antônio Leal; Barreto, João Erivan Façanha; Martins, Dainesy Santos; de Souza Pimentel, Paulo Vitor; da Silva Costa, Deiziane Viana; e Silva, Reyca Rodrigues; de Souza, Luan Kelves Miranda; de Lima, Camila Nayane Carvalho; Rocha, Jefferson Almeida; de Freitas, Ana Paula Fragoso; da Silva, Durcilene Alves; Scafuri, Ariel Gustavo; de Leitão, Renata Ferreira Carvalho; de Castro Brito, Gerly Anne; Medeiros, Jand Venes Rolim; Cerqueira, Gilberto Santos. 2019. "Protective Effect of Cashew Gum (Anacardium occidentale L.) on 5-Fluorouracil-Induced Intestinal Mucositis." Pharmaceuticals 12, no. 2: 51.
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