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Protective Effect of Cashew Gum (Anacardium occidentale L.) on 5-Fluorouracil-Induced Intestinal Mucositis

1
Department of Morphology, Faculty of Medicine, Federal University of Ceará, s/n Delmiro de Farias Street, Porangabuçu Campus, Fortaleza 60416-030, Brazil
2
Biotechnology and Biodiversity Center Research, BIOTEC, Federal University of Piauí, Parnaíba, Piauí 64202-020, Brazil
3
Nucleus of Research and Development of Medications (NPDM), Federal University of Ceará, Coronel Nunes de Melo Street, 100, Fortaleza 60430-275, Brazil
4
Research Group in Natural Sciences and Biotechnology, Federal University of Maranhão, s/n Avenue Aurila Maria Santos Barros de Sousa, Frei Alberto Beretta, Grajaú-MA 65940-000, Brazil
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2019, 12(2), 51; https://doi.org/10.3390/ph12020051
Received: 31 December 2018 / Revised: 27 February 2019 / Accepted: 15 March 2019 / Published: 3 April 2019
(This article belongs to the Special Issue Anticancer Drugs)
Intestinal mucositis is a common complication associated with 5-fluorouracil (5-FU), a chemotherapeutic agent used for cancer treatment. Cashew gum (CG) has been reported as a potent anti-inflammatory agent. In the present study, we aimed to evaluate the effect of CG extracted from the exudate of Anacardium occidentale L. on experimental intestinal mucositis induced by 5-FU. Swiss mice were randomly divided into seven groups: Saline, 5-FU, CG 30, CG 60, CG 90, Celecoxib (CLX), and CLX + CG 90 groups. The weight of mice was measured daily. After treatment, the animals were euthanized and segments of the small intestine were collected to evaluate histopathological alterations (morphometric analysis), levels of malondialdehyde (MDA), myeloperoxidase (MPO), and glutathione (GSH), and immunohistochemical analysis of interleukin 1 beta (IL-1β) and cyclooxygenase-2 (COX-2). 5-FU induced intense weight loss and reduction in villus height compared to the saline group. CG 90 prevented 5-FU-induced histopathological changes and decreased oxidative stress through decrease of MDA levels and increase of GSH concentration. CG attenuated inflammatory process by decreasing MPO activity, intestinal mastocytosis, and COX-2 expression. Our findings suggest that CG at a concentration of 90 mg/kg reverses the effects of 5-FU-induced intestinal mucositis. View Full-Text
Keywords: intestinal mucositis; heteropolysaccharide; 5-fluorouracil; inflammation intestinal mucositis; heteropolysaccharide; 5-fluorouracil; inflammation
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MDPI and ACS Style

Miranda, J.A.L.d.; Barreto, J.E.F.; Martins, D.S.; Pimentel, P.V.d.S.; Costa, D.V.d.S.; Silva, R.R.e; Souza, L.K.M.d.; Lima, C.N.d.C.; Rocha, J.A.; Freitas, A.P.F.d.; Silva, D.A.d.; Scafuri, A.G.; Leitão, R.F.d.C.; Brito, G.A.d.C.; Medeiros, J.V.R.; Cerqueira, G.S. Protective Effect of Cashew Gum (Anacardium occidentale L.) on 5-Fluorouracil-Induced Intestinal Mucositis. Pharmaceuticals 2019, 12, 51. https://doi.org/10.3390/ph12020051

AMA Style

Miranda JALd, Barreto JEF, Martins DS, Pimentel PVdS, Costa DVdS, Silva RRe, Souza LKMd, Lima CNdC, Rocha JA, Freitas APFd, Silva DAd, Scafuri AG, Leitão RFdC, Brito GAdC, Medeiros JVR, Cerqueira GS. Protective Effect of Cashew Gum (Anacardium occidentale L.) on 5-Fluorouracil-Induced Intestinal Mucositis. Pharmaceuticals. 2019; 12(2):51. https://doi.org/10.3390/ph12020051

Chicago/Turabian Style

Miranda, João A.L.d.; Barreto, João E.F.; Martins, Dainesy S.; Pimentel, Paulo V.d.S.; Costa, Deiziane V.d.S.; Silva, Reyca R.e; Souza, Luan K.M.d.; Lima, Camila N.d.C.; Rocha, Jefferson A.; Freitas, Ana P.F.d.; Silva, Durcilene A.d.; Scafuri, Ariel G.; Leitão, Renata F.d.C.; Brito, Gerly A.d.C.; Medeiros, Jand V.R.; Cerqueira, Gilberto S. 2019. "Protective Effect of Cashew Gum (Anacardium occidentale L.) on 5-Fluorouracil-Induced Intestinal Mucositis" Pharmaceuticals 12, no. 2: 51. https://doi.org/10.3390/ph12020051

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