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Pharmaceuticals 2019, 12(1), 30; https://doi.org/10.3390/ph12010030

Iron in Lung Pathology

1
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
2
Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
*
Author to whom correspondence should be addressed.
Received: 14 December 2018 / Revised: 30 January 2019 / Accepted: 10 February 2019 / Published: 15 February 2019
(This article belongs to the Special Issue Iron as Therapeutic Targets in Human Diseases)
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Abstract

The lung presents a unique challenge for iron homeostasis. The entire airway is in direct contact with the environment and its iron particulate matter and iron-utilizing microbes. However, the homeostatic and adaptive mechanisms of pulmonary iron regulation are poorly understood. This review provides an overview of systemic and local lung iron regulation, as well as the roles of iron in the development of lung infections, airway disease, and lung injury. These mechanisms provide an important foundation for the ongoing development of therapeutic applications. View Full-Text
Keywords: hepcidin; iron; lung; acute lung injury; COPD; lung infection; cystic fibrosis hepcidin; iron; lung; acute lung injury; COPD; lung infection; cystic fibrosis
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Zhang, V.; Nemeth, E.; Kim, A. Iron in Lung Pathology. Pharmaceuticals 2019, 12, 30.

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