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Pharmaceuticals 2019, 12(1), 23; https://doi.org/10.3390/ph12010023

Modulators of Transient Receptor Potential (TRP) Channels as Therapeutic Options in Lung Disease

Walther-Straub-Institute of Pharmacology and Toxicology, Member of the German Center for Lung Research (DZL), LMU Munich, Nussbaumstr. 26, D-80336 Munich, Germany
Received: 15 January 2019 / Revised: 28 January 2019 / Accepted: 29 January 2019 / Published: 1 February 2019
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Abstract

The lungs are essential for gas exchange and serve as the gateways of our body to the external environment. They are easily accessible for drugs from both sides, the airways and the vasculature. Recent literature provides evidence for a role of Transient Receptor Potential (TRP) channels as chemosensors and essential members of signal transduction cascades in stress-induced cellular responses. This review will focus on TRP channels (TRPA1, TRPC6, TRPV1, and TRPV4), predominantly expressed in non-neuronal lung tissues and their involvement in pathways associated with diseases like asthma, cystic fibrosis, chronic obstructive pulmonary disease (COPD), lung fibrosis, and edema formation. Recently identified specific modulators of these channels and their potential as new therapeutic options as well as strategies for a causal treatment based on the mechanistic understanding of molecular events will also be evaluated. View Full-Text
Keywords: non-neuronal; transient receptor potential (TRP) channels; TRPA1; TRPC6; TRPV1; TRPV4; lung; asthma; cystic fibrosis; lung fibrosis; lung edema; chronic obstructive pulmonary disease (COPD) non-neuronal; transient receptor potential (TRP) channels; TRPA1; TRPC6; TRPV1; TRPV4; lung; asthma; cystic fibrosis; lung fibrosis; lung edema; chronic obstructive pulmonary disease (COPD)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Dietrich, A. Modulators of Transient Receptor Potential (TRP) Channels as Therapeutic Options in Lung Disease. Pharmaceuticals 2019, 12, 23.

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