Next Article in Journal / Special Issue
Smart Bandage Based on Molecularly Imprinted Polymers (MIPs) for Diclofenac Controlled Release
Previous Article in Journal
Role of Chemosensory TRP Channels in Lung Cancer
Previous Article in Special Issue
Low Molecular Weight Chitosan-Coated PLGA Nanoparticles for Pulmonary Delivery of Tobramycin for Cystic Fibrosis
Article Menu
Issue 4 (December) cover image

Export Article

Open AccessArticle
Pharmaceuticals 2018, 11(4), 91; https://doi.org/10.3390/ph11040091

A Novel PAA Derivative with Enhanced Drug Efficacy in Pancreatic Cancer Cell Lines

1
Institute of Science and Technology in Medicine, Keele University, Keele ST5 5BG, UK
2
College of Dentistry, University of Basrah, Basrah 61004, Iraq
3
School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen AB10 7GJ, UK
4
School of Pharmacy, Queen’s University Belfast, Belfast BT9 7BL, UK
*
Authors to whom correspondence should be addressed.
Received: 8 August 2018 / Revised: 18 September 2018 / Accepted: 19 September 2018 / Published: 22 September 2018
(This article belongs to the Special Issue Nano Drug Carriers)
Full-Text   |   PDF [4092 KB, uploaded 22 September 2018]   |  

Abstract

Nanoparticles have been shown to be effective drug carriers in cancer therapy. Pancreatic cancer forms dense tumours which are often resistant to drug molecules. In order to overcome such multidrug resistance, new drug entities, novel delivery systems and combination therapy strategies are being explored. In this paper, we report the design and synthesis of a poly(allylamine)-based amphiphile modified with hydrophobic naphthalimido pendant groups. Bisnaphthalimide compounds have been shown to possess anticancer activity. The potential of this polymer to encapsulate, solubilize and enhance drug (5-fluorouricil and bis-(naphthalimidopropyl)-diaminooctane) cytotoxicity in BxPC-3 cells was evaluated. Our studies showed that the insoluble drugs could be formulated up to 4.3 mg mL−1 and 2.4 mg mL−1 inside the amphiphiles, respectively. Additionally, the novel poly(allylamine)-naphthalimide carrier resulted in an amplification of cytotoxic effect with drug treatment after 24 h, and was capable of reduction of 50% cell population at concentrations as low as 3 μg mL−1. View Full-Text
Keywords: nanomedicine; nanopharmaceutics; drug solubilisation; pancreatic cancer; bisnaphthalimide nanomedicine; nanopharmaceutics; drug solubilisation; pancreatic cancer; bisnaphthalimide
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Alsuraifi, A.; Lin, P.K.T.; Curtis, A.; Lamprou, D.A.; Hoskins, C. A Novel PAA Derivative with Enhanced Drug Efficacy in Pancreatic Cancer Cell Lines. Pharmaceuticals 2018, 11, 91.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top