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Open AccessArticle

A Novel PAA Derivative with Enhanced Drug Efficacy in Pancreatic Cancer Cell Lines

Institute of Science and Technology in Medicine, Keele University, Keele ST5 5BG, UK
College of Dentistry, University of Basrah, Basrah 61004, Iraq
School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen AB10 7GJ, UK
School of Pharmacy, Queen’s University Belfast, Belfast BT9 7BL, UK
Authors to whom correspondence should be addressed.
Pharmaceuticals 2018, 11(4), 91;
Received: 8 August 2018 / Revised: 18 September 2018 / Accepted: 19 September 2018 / Published: 22 September 2018
(This article belongs to the Special Issue Nano Drug Carriers)
Nanoparticles have been shown to be effective drug carriers in cancer therapy. Pancreatic cancer forms dense tumours which are often resistant to drug molecules. In order to overcome such multidrug resistance, new drug entities, novel delivery systems and combination therapy strategies are being explored. In this paper, we report the design and synthesis of a poly(allylamine)-based amphiphile modified with hydrophobic naphthalimido pendant groups. Bisnaphthalimide compounds have been shown to possess anticancer activity. The potential of this polymer to encapsulate, solubilize and enhance drug (5-fluorouricil and bis-(naphthalimidopropyl)-diaminooctane) cytotoxicity in BxPC-3 cells was evaluated. Our studies showed that the insoluble drugs could be formulated up to 4.3 mg mL−1 and 2.4 mg mL−1 inside the amphiphiles, respectively. Additionally, the novel poly(allylamine)-naphthalimide carrier resulted in an amplification of cytotoxic effect with drug treatment after 24 h, and was capable of reduction of 50% cell population at concentrations as low as 3 μg mL−1. View Full-Text
Keywords: nanomedicine; nanopharmaceutics; drug solubilisation; pancreatic cancer; bisnaphthalimide nanomedicine; nanopharmaceutics; drug solubilisation; pancreatic cancer; bisnaphthalimide
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Alsuraifi, A.; Lin, P.K.T.; Curtis, A.; Lamprou, D.A.; Hoskins, C. A Novel PAA Derivative with Enhanced Drug Efficacy in Pancreatic Cancer Cell Lines. Pharmaceuticals 2018, 11, 91.

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