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Pharmaceuticals 2018, 11(4), 125; https://doi.org/10.3390/ph11040125

TRPM8 Channels and Dry Eye

1
Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju 61469, Korea
2
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea
3
School of Public Health, University of California, Berkeley, CA 94720, USA
4
Department of Dermatology, Chonnam National University Medical School and Hospital, Gwangju 61469, Korea
*
Author to whom correspondence should be addressed.
Received: 17 September 2018 / Revised: 5 November 2018 / Accepted: 12 November 2018 / Published: 15 November 2018
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Abstract

Transient receptor potential (TRP) channels transduce signals of chemical irritation and temperature change from the ocular surface to the brain. Dry eye disease (DED) is a multifactorial disorder wherein the eyes react to trivial stimuli with abnormal sensations, such as dryness, blurring, presence of foreign body, discomfort, irritation, and pain. There is increasing evidence of TRP channel dysfunction (i.e., TRPV1 and TRPM8) in DED pathophysiology. Here, we review some of this literature and discuss one strategy on how to manage DED using a TRPM8 agonist. View Full-Text
Keywords: transient receptor potential; dry eye disease; TRPV; TRPM8 transient receptor potential; dry eye disease; TRPV; TRPM8
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Yang, J.M.; Wei, E.T.; Kim, S.J.; Yoon, K.C. TRPM8 Channels and Dry Eye. Pharmaceuticals 2018, 11, 125.

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