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Pharmaceuticals 2017, 10(4), 96; https://doi.org/10.3390/ph10040096

Biodegradable Scaffolds for Bone Regeneration Combined with Drug-Delivery Systems in Osteomyelitis Therapy

1
Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy
2
Center of Health Technology, University of Pavia, Via Ferrata 1, 27100 Pavia, Italy
3
Centre oh Health Technology (CHT), Via Ferrata 1, University of Pavia, 27100 Pavia, Italy
4
Department of Molecular Medicine, University of Pavia, Viale Taramelli 2, 27100 Pavia, Italy
*
Author to whom correspondence should be addressed.
Received: 1 October 2017 / Revised: 27 November 2017 / Accepted: 29 November 2017 / Published: 12 December 2017
(This article belongs to the Special Issue Tissue-Protective Agents: New Drugs and Technologies)
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Abstract

A great deal of research is ongoing in the area of tissue engineering (TE) for bone regeneration. A possible improvement in restoring damaged tissues involves the loading of drugs such as proteins, genes, growth factors, antibiotics, and anti-inflammatory drugs into scaffolds for tissue regeneration. This mini-review is focused on the combination of the local delivery of antibiotic agents with bone regenerative therapy for the treatment of a severe bone infection such as osteomyelitis. The review includes a brief explanation of scaffolds for bone regeneration including scaffolds characteristics and types, a focus on severe bone infections (especially osteomyelitis and its treatment), and a literature review of local antibiotic delivery by the combination of scaffolds and drug-delivery systems. Some examples related to published studies on gentamicin sulfate-loaded drug-delivery systems combined with scaffolds are discussed, and future perspectives are highlighted. View Full-Text
Keywords: bone regeneration; osteomyelitis; scaffold; gentamicin; antibiotics bone regeneration; osteomyelitis; scaffold; gentamicin; antibiotics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Dorati, R.; DeTrizio, A.; Modena, T.; Conti, B.; Benazzo, F.; Gastaldi, G.; Genta, I. Biodegradable Scaffolds for Bone Regeneration Combined with Drug-Delivery Systems in Osteomyelitis Therapy. Pharmaceuticals 2017, 10, 96.

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