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From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics
Open AccessReview

Design Strategies for Electrochemical Aptasensors for Cancer Diagnostic Devices

1
Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima Str. 10, 10-748 Olsztyn, Poland
2
Interdisciplinary Nanoscience Center (iNANO), Faculty of Science and Technology, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark
*
Author to whom correspondence should be addressed.
Academic Editor: Paolo Bertoncello
Sensors 2021, 21(3), 736; https://doi.org/10.3390/s21030736
Received: 14 December 2020 / Revised: 12 January 2021 / Accepted: 18 January 2021 / Published: 22 January 2021
(This article belongs to the Special Issue Electrochemical Aptamer-Based Biosensors)
Improved outcomes for many types of cancer achieved during recent years is due, among other factors, to the earlier detection of tumours and the greater availability of screening tests. With this, non-invasive, fast and accurate diagnostic devices for cancer diagnosis strongly improve the quality of healthcare by delivering screening results in the most cost-effective and safe way. Biosensors for cancer diagnostics exploiting aptamers offer several important advantages over traditional antibodies-based assays, such as the in-vitro aptamer production, their inexpensive and easy chemical synthesis and modification, and excellent thermal stability. On the other hand, electrochemical biosensing approaches allow sensitive, accurate and inexpensive way of sensing, due to the rapid detection with lower costs, smaller equipment size and lower power requirements. This review presents an up-to-date assessment of the recent design strategies and analytical performance of the electrochemical aptamer-based biosensors for cancer diagnosis and their future perspectives in cancer diagnostics. View Full-Text
Keywords: aptasensor; aptamer; cancer biomarkers; electrochemical biosensors aptasensor; aptamer; cancer biomarkers; electrochemical biosensors
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MDPI and ACS Style

Malecka, K.; Mikuła, E.; Ferapontova, E.E. Design Strategies for Electrochemical Aptasensors for Cancer Diagnostic Devices. Sensors 2021, 21, 736. https://doi.org/10.3390/s21030736

AMA Style

Malecka K, Mikuła E, Ferapontova EE. Design Strategies for Electrochemical Aptasensors for Cancer Diagnostic Devices. Sensors. 2021; 21(3):736. https://doi.org/10.3390/s21030736

Chicago/Turabian Style

Malecka, Kamila; Mikuła, Edyta; Ferapontova, Elena E. 2021. "Design Strategies for Electrochemical Aptasensors for Cancer Diagnostic Devices" Sensors 21, no. 3: 736. https://doi.org/10.3390/s21030736

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