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Volume 21
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10.3390/s21020643
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Article

Hyperspectral Imagery for Assessing Laser-Induced Thermal State Change in Liver

by
Martina De Landro
1,†,
Ignacio Espíritu García-Molina
1,†,
Manuel Barberio
2,3,
Eric Felli
2,
Vincent Agnus
2,
Margherita Pizzicannella
2,
Michele Diana
2,4,5,
Emanuele Zappa
1 and
Paola Saccomandi
1,*
1
Department of Mechanical Engineering, Politecnico di Milano, 20156 Milan, Italy
2
IHU-Strasbourg, 67000 Strasbourg, France
3
Department of General Surgery, Ospedale Card. G. Panico, 73039 Tricase, Italy
4
Research Institute against Cancer of the Digestive System IRCAD, 67091 Strasbourg, France
5
ICube Laboratory, Photonics Instrumentation for Health, 67400 Strasbourg, France
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Academic Editor: César Sanz
Sensors 2021, 21(2), 643; https://doi.org/10.3390/s21020643
Received: 3 December 2020 / Revised: 5 January 2021 / Accepted: 13 January 2021 / Published: 18 January 2021
(This article belongs to the Special Issue Trends and Prospects in Medical Hyperspectral Imagery)
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Abstract

This work presents the potential of hyperspectral imaging (HSI) to monitor the thermal outcome of laser ablation therapy used for minimally invasive tumor removal. Our main goal is the establishment of indicators of the thermal damage of living tissues, which can be used to assess the effect of the procedure. These indicators rely on the spectral variation of temperature-dependent tissue chromophores, i.e., oxyhemoglobin, deoxyhemoglobin, methemoglobin, and water. Laser treatment was performed at specific temperature thresholds (from 60 to 110 °C) on in-vivo animal liver and was assessed with a hyperspectral camera (500–995 nm) during and after the treatment. The indicators were extracted from the hyperspectral images after the following processing steps: the breathing motion compensation and the spectral and spatial filtering, the selection of spectral bands corresponding to specific tissue chromophores, and the analysis of the areas under the curves for each spectral band. Results show that properly combining spectral information related to deoxyhemoglobin, methemoglobin, lipids, and water allows for the segmenting of different zones of the laser-induced thermal damage. This preliminary investigation provides indicators for describing the thermal state of the liver, which can be employed in the future as clinical endpoints of the procedure outcome. View Full-Text
Keywords: hyperspectral imaging; image processing; image segmentation; laser ablation; tissue chromophores; thermal damage; temperature-dependent tissue chromophores; methemoglobin hyperspectral imaging; image processing; image segmentation; laser ablation; tissue chromophores; thermal damage; temperature-dependent tissue chromophores; methemoglobin
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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MDPI and ACS Style

De Landro, M.; Espíritu García-Molina, I.; Barberio, M.; Felli, E.; Agnus, V.; Pizzicannella, M.; Diana, M.; Zappa, E.; Saccomandi, P. Hyperspectral Imagery for Assessing Laser-Induced Thermal State Change in Liver. Sensors 2021, 21, 643. https://doi.org/10.3390/s21020643

AMA Style

De Landro M, Espíritu García-Molina I, Barberio M, Felli E, Agnus V, Pizzicannella M, Diana M, Zappa E, Saccomandi P. Hyperspectral Imagery for Assessing Laser-Induced Thermal State Change in Liver. Sensors. 2021; 21(2):643. https://doi.org/10.3390/s21020643

Chicago/Turabian Style

De Landro, Martina, Ignacio Espíritu García-Molina, Manuel Barberio, Eric Felli, Vincent Agnus, Margherita Pizzicannella, Michele Diana, Emanuele Zappa, and Paola Saccomandi. 2021. "Hyperspectral Imagery for Assessing Laser-Induced Thermal State Change in Liver" Sensors 21, no. 2: 643. https://doi.org/10.3390/s21020643

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