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Volume 21
Issue 16
10.3390/s21165538
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Communication

Copper (II) Ion-Modified Gold Nanoclusters as Peroxidase Mimetics for the Colorimetric Detection of Pyrophosphate

by
Yunjing Shi
1,
Jinjie Wang
1,*,
Kun Mu
1,
Suqin Liu
1,
Guang Yang
2,
Min Zhang
1 and
Jingxia Yang
1
1
College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, 333 Longteng Road, Shanghai 201620, China
2
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Road, Shanghai 201620, China
*
Author to whom correspondence should be addressed.
Sensors 2021, 21(16), 5538; https://doi.org/10.3390/s21165538
Submission received: 14 July 2021 / Revised: 1 August 2021 / Accepted: 15 August 2021 / Published: 17 August 2021
(This article belongs to the Section Chemical Sensors)
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Abstract

Copper (II) ions have been shown to greatly improve the chemical stability and peroxidase-like activity of gold nanoclusters (AuNCs). Since the affinity between Cu2+ and pyrophosphate (PPi) is higher than that between Cu2+ and AuNCs, the catalytic activity of AuNCs-Cu2+ decreases with the introduction of PPi. Based on this principle, a new colorimetric detection method of PPi with high sensitivity and selectivity was developed by using AuNCs-Cu2+ as a probe. Under optimized conditions, the detection limit of PPi was 0.49 nM with a linear range of 0.51 to 30,000 nM. The sensitivity of the method was three orders of magnitude higher than that of a fluorescence method using AuNCs-Cu2+ as the probe. Finally, the AuNCs-Cu2+ system was successfully applied to directly determine the concentration of PPi in human urine samples.
Keywords: gold nanocluster; copper ion; pyrophosphate; keratin; colorimetric detection gold nanocluster; copper ion; pyrophosphate; keratin; colorimetric detection
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MDPI and ACS Style

Shi, Y.; Wang, J.; Mu, K.; Liu, S.; Yang, G.; Zhang, M.; Yang, J. Copper (II) Ion-Modified Gold Nanoclusters as Peroxidase Mimetics for the Colorimetric Detection of Pyrophosphate. Sensors 2021, 21, 5538. https://doi.org/10.3390/s21165538

AMA Style

Shi Y, Wang J, Mu K, Liu S, Yang G, Zhang M, Yang J. Copper (II) Ion-Modified Gold Nanoclusters as Peroxidase Mimetics for the Colorimetric Detection of Pyrophosphate. Sensors. 2021; 21(16):5538. https://doi.org/10.3390/s21165538

Chicago/Turabian Style

Shi, Yunjing, Jinjie Wang, Kun Mu, Suqin Liu, Guang Yang, Min Zhang, and Jingxia Yang. 2021. "Copper (II) Ion-Modified Gold Nanoclusters as Peroxidase Mimetics for the Colorimetric Detection of Pyrophosphate" Sensors 21, no. 16: 5538. https://doi.org/10.3390/s21165538

APA Style

Shi, Y., Wang, J., Mu, K., Liu, S., Yang, G., Zhang, M., & Yang, J. (2021). Copper (II) Ion-Modified Gold Nanoclusters as Peroxidase Mimetics for the Colorimetric Detection of Pyrophosphate. Sensors, 21(16), 5538. https://doi.org/10.3390/s21165538

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