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Electrochemical Biosensors Based on S-Layer Proteins

by 1,2,3 and 2,*
Department of Biochemistry, Faculty of Science, King Abdulaziz University (KAU), Jeddah 21589, Saudi Arabia
Institute for Synthetic Bioarchitectures, Department of NanoBiotechnology, BOKU - University of Natural Resources and Life Sciences, Vienna, Muthgasse 11, 1190 Vienna, Austria
Current address: Division of Nanobiotechnology, Department of Protein Science, Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 171 21 Solna, Stockholm, Sweden
Author to whom correspondence should be addressed.
Sensors 2020, 20(6), 1721;
Received: 12 February 2020 / Revised: 5 March 2020 / Accepted: 17 March 2020 / Published: 19 March 2020
Designing and development of electrochemical biosensors enable molecule sensing and quantification of biochemical compositions with multitudinous benefits such as monitoring, detection, and feedback for medical and biotechnological applications. Integrating bioinspired materials and electrochemical techniques promote specific, rapid, sensitive, and inexpensive biosensing platforms for (e.g., point-of-care testing). The selection of biomaterials to decorate a biosensor surface is a critical issue as it strongly affects selectivity and sensitivity. In this context, smart biomaterials with the intrinsic self-assemble capability like bacterial surface (S-) layer proteins are of paramount importance. Indeed, by forming a crystalline two-dimensional protein lattice on many sensors surfaces and interfaces, the S-layer lattice constitutes an immobilization matrix for small biomolecules and lipid membranes and a patterning structure with unsurpassed spatial distribution for sensing elements and bioreceptors. This review aims to highlight on exploiting S-layer proteins in biosensor technology for various applications ranging from detection of metal ions over small organic compounds to cells. Furthermore, enzymes immobilized on the S-layer proteins allow specific detection of several vital biomolecules. The special features of the S-layer protein lattice as part of the sensor architecture enhances surface functionalization and thus may feature an innovative class of electrochemical biosensors. View Full-Text
Keywords: S-layer proteins; biosensor; biocompatible layer; self-assembly; bioinspired material S-layer proteins; biosensor; biocompatible layer; self-assembly; bioinspired material
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MDPI and ACS Style

Damiati, S.; Schuster, B. Electrochemical Biosensors Based on S-Layer Proteins. Sensors 2020, 20, 1721.

AMA Style

Damiati S, Schuster B. Electrochemical Biosensors Based on S-Layer Proteins. Sensors. 2020; 20(6):1721.

Chicago/Turabian Style

Damiati, Samar, and Bernhard Schuster. 2020. "Electrochemical Biosensors Based on S-Layer Proteins" Sensors 20, no. 6: 1721.

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