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Open AccessCommunication

Tomographic Ultrasound and LED-Based Photoacoustic System for Preclinical Imaging

1
Biomedical Photonics Imaging (BMPI), Technical Medical Center, University of Twente, 7522 NH Enschede, The Netherlands
2
Translational Liver Research, Medical Cell BioPhysics (MCBP), Technical Medical Center, University of Twente, 7522 NH Enschede, The Netherlands
*
Authors to whom correspondence should be addressed.
Sensors 2020, 20(10), 2793; https://doi.org/10.3390/s20102793
Received: 17 April 2020 / Revised: 8 May 2020 / Accepted: 11 May 2020 / Published: 14 May 2020
Small animals are widely used as disease models in medical research. Noninvasive imaging modalities with functional capability play an important role in studying the disease state and treatment progress. Photoacoustics, being a noninvasive and functional modality, has the potential for small-animal imaging. However, the conventional photoacoustic tomographic systems use pulsed lasers, making it expensive, bulky, and require long acquisition time. In this work, we propose the use of photoacoustic and ultrasound tomographic imaging with LEDs as the light source and acoustic detection using a linear transducer array. We have demonstrated full-view tomographic imaging of a euthanized mouse and a potential application in liver fibrosis research. View Full-Text
Keywords: tomography; photoacoustic; ultrasound; small animal; liver; fibrosis tomography; photoacoustic; ultrasound; small animal; liver; fibrosis
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Francis, K.J.; Booijink, R.; Bansal, R.; Steenbergen, W. Tomographic Ultrasound and LED-Based Photoacoustic System for Preclinical Imaging. Sensors 2020, 20, 2793.

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