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Open AccessArticle

Competitive USB-Powered Hand-Held Potentiostat for POC Applications: An HRP Detection Case

1
Department of Electronics and Biomedical Engineering, Faculty of Physics, Universitat de Barcelona, 08028 Barcelona, Spain
2
Diagnostic Nanotools Group, Cibbim-Nanomedicine, Vall Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, 08035 Barcelona, Spain
3
CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
Sensors 2019, 19(24), 5388; https://doi.org/10.3390/s19245388
Received: 10 November 2019 / Revised: 27 November 2019 / Accepted: 3 December 2019 / Published: 6 December 2019
(This article belongs to the Section Biosensors)
Considerable efforts are made to develop Point-of-Care (POC) diagnostic tests. POC devices have the potential to match or surpass conventional systems regarding time, accuracy, and cost, and they are significantly easier to operate by or close to the patient. This strongly depends on the availability of miniaturized measurement equipment able to provide a fast and sensitive response. This paper presents a low-cost, portable, miniaturized USB-powered potentiostat for electrochemical analysis, which has been designed, fabricated, characterized, and tested against three forms of high-cost commercial equipment. The portable platform has a final size of 10.5 × 5.8 × 2.5 cm, a weight of 41 g, and an approximate manufacturing cost of $85 USD. It includes three main components: the power module which generates a stable voltage and a negative supply, the front-end module that comprises a dual-supply potentiostat, and the back-end module, composed of a microcontroller unit and a LabVIEW-based graphic user interface, granting plug-and-play and easy-to-use operation on any computer. The performance of this prototype was evaluated by detecting chronoamperometrically horseradish peroxidase (HRP), the enzymatic label most widely used in electrochemical biosensors. As will be shown, the miniaturized platform detected HRP at concentrations ranging from 0.01 ng·mL−1 to 1 µg·mL−1, with results comparable to those obtained with the three commercial electrochemical systems. View Full-Text
Keywords: horseradish peroxidase (HRP) chronoamperometry; electrochemical biosensor; reconfigurable potentiostat; portable; low-cost electronics; USB-powered horseradish peroxidase (HRP) chronoamperometry; electrochemical biosensor; reconfigurable potentiostat; portable; low-cost electronics; USB-powered
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Montes-Cebrián, Y.; Álvarez-Carulla, A.; Ruiz-Vega, G.; Colomer-Farrarons, J.; Puig-Vidal, M.; Baldrich, E.; Miribel-Català, P.L. Competitive USB-Powered Hand-Held Potentiostat for POC Applications: An HRP Detection Case. Sensors 2019, 19, 5388.

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