Next Article in Journal
Filtered Multitone Modulation Underwater Acoustic Communications Using Low-Complexity Channel-Estimation-Based MMSE Turbo Equalization
Previous Article in Journal
Two-Stage Latent Dynamics Modeling and Filtering for Characterizing Individual Walking and Running Patterns with Smartphone Sensors
Open AccessCommunication

Investigation of Polyurethane Matrix Membranes for Salivary Nitrate ISFETs to Prevent the Drift

1
Aist-Osaka University Advanced Photonics and Biosensing Open Innovation Laboratory, AIST, Suita 565-0043, Japan
2
Department of Applied Physics, Graduate School of Engineering, Osaka University, Suita 565-0043, Japan
3
Department of Applied Chemistry, Graduate School of Engineering, Osaka Institute of Technology, Osaka 535-8585, Japan
4
National Institute of Technology, Toba College, Toba 517-8501, Japan
*
Author to whom correspondence should be addressed.
Sensors 2019, 19(12), 2713; https://doi.org/10.3390/s19122713
Received: 11 April 2019 / Revised: 5 June 2019 / Accepted: 14 June 2019 / Published: 17 June 2019
(This article belongs to the Section Sensor Materials)
We have investigated human-stress monitoring by making use of salivary nitrate, which can be a candidate for stress markers, with ion-selective field-effect transistors (ISFETs). ISFETs are suitable for on-site single-drop analysis of salivary nitrate within 10 s. However, when ISFETs are used for salivary nitrate, ISFETs have a problem that is called the initial drift. The initial drift makes accurate nitrate monitoring difficult. Thus, the purpose of this study is to prevent the initial drift and to search for a new, simple polymer to possess a better performance of sensor responses than conventional matrix membranes, such as PVC. In this research, we investigated ISFETs using specific matrix membranes, for example KP-13, Pellethane®­­, and P7281-PU. The initial drift was evaluated from the fluctuations of the response values generated by the ISFETs when immersed in saliva or aqueous solution. As a result, P7281-PU showed a prevention effect on the initial drift, both in the whole saliva and in various solutions. Furthermore, the cause of drift may be H+ diffusion, and the drift prevention effect of P7281-PU may be affected by urethane bond capturing H+ in the ion-selective membrane. This result suggests that a continuous nitrate monitoring is feasible and may be applied to wearable sensors. View Full-Text
Keywords: ISFETs; ISE; polyurethane; salivary nitrate; stress; drift; ion-selective membrane ISFETs; ISE; polyurethane; salivary nitrate; stress; drift; ion-selective membrane
Show Figures

Figure 1

MDPI and ACS Style

Osaki, S.; Kintoki, T.; Moriuchi-Kawakami, T.; Kitamura, K.; Wakida, S.-I. Investigation of Polyurethane Matrix Membranes for Salivary Nitrate ISFETs to Prevent the Drift. Sensors 2019, 19, 2713.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop