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Sensors 2018, 18(8), 2550;

Remote Cell Growth Sensing Using Self-Sustained Bio-Oscillations

Instituto de Microelectrónica de Sevilla, IMSE, CNM (Universidad de Sevilla, CSIC), Av. Américo Vespucio, SN, 41092 Sevilla, Spain
Departamento de Tecnología Electrónica, Escuela Técnica Superior de Ingeniería Informática, Universidad de Sevilla, Av. Reina Mercedes, SN, 41012 Sevilla, Spain
Departamento de Electrónica y Electromagnetismo, Facultad de Física, Universidad de Sevilla, Av. Reina Mercedes, SN, 41012 Sevilla, Spain
Departamento de Biología Celular, Facultad de Biología, Universidad de Sevilla, Av. Reina Mercedes, SN, 41012 Sevilla, Spain
Authors to whom correspondence should be addressed.
Received: 8 June 2018 / Revised: 12 July 2018 / Accepted: 1 August 2018 / Published: 3 August 2018
(This article belongs to the Special Issue Smart Sensing System for Real-Time Monitoring)
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A smart sensor system for cell culture real-time supervision is proposed, allowing for a significant reduction in human effort applied to this type of assay. The approach converts the cell culture under test into a suitable “biological” oscillator. The system enables the remote acquisition and management of the “biological” oscillation signals through a secure web interface. The indirectly observed biological properties are cell growth and cell number, which are straightforwardly related to the measured bio-oscillation signal parameters, i.e., frequency and amplitude. The sensor extracts the information without complex circuitry for acquisition and measurement, taking advantage of the microcontroller features. A discrete prototype for sensing and remote monitoring is presented along with the experimental results obtained from the performed measurements, achieving the expected performance and outcomes. View Full-Text
Keywords: smart sensing; bioimpedance; cell culture; OBT; real-time monitoring smart sensing; bioimpedance; cell culture; OBT; real-time monitoring

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Pérez, P.; Huertas, G.; Olmo, A.; Maldonado-Jacobi, A.; Serrano, J.A.; Martín, M.E.; Daza, P.; Yúfera, A. Remote Cell Growth Sensing Using Self-Sustained Bio-Oscillations. Sensors 2018, 18, 2550.

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