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Sensors 2017, 17(5), 1180;

Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC)

Institute of Nano Electronic Engineering (INEE), Universiti Malaysia Perlis, Kangar, Perlis 01000, Malaysia
Advanced Medical & Dental Institute (AMDI), Universiti Sains Malaysia, Kepala Batas, Penang 13200, Malaysia
Author to whom correspondence should be addressed.
Academic Editor: Giovanna Marrazza
Received: 10 March 2017 / Revised: 17 April 2017 / Accepted: 18 April 2017 / Published: 22 May 2017
(This article belongs to the Special Issue Aptasensors 2016)
Full-Text   |   PDF [2128 KB, uploaded 22 May 2017]   |  


Anxiety is a psychological problem that often emerges during the normal course of human life. The detection of anxiety often involves a physical exam and a self-reporting questionnaire. However, these approaches have limitations, as the data might lack reliability and consistency upon application to the same population over time. Furthermore, there might be varying understanding and interpretations of the particular question by the participant, which necessitating the approach of using biomarker-based measurement for stress diagnosis. The most prominent biomarker related to stress, hormone cortisol, plays a key role in the fight-or-flight situation, alters the immune response, and suppresses the digestive and the reproductive systems. We have taken the endeavour to review the available aptamer-based biosensor (aptasensor) for cortisol detection. The potential point-of-care diagnostic strategies that could be harnessed for the aptasensing of cortisol were also envisaged. View Full-Text
Keywords: anxiety; cortisol; aptasensor; aptamer anxiety; cortisol; aptasensor; aptamer

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Zainol Abidin, A.S.; Rahim, R.A.; Md Arshad, M.K.; Fatin Nabilah, M.F.; Voon, C.H.; Tang, T.-H.; Citartan, M. Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC). Sensors 2017, 17, 1180.

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