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Sensors 2016, 16(4), 544;

Intra-Tissue Pressure Measurement in Ex Vivo Liver Undergoing Laser Ablation with Fiber-Optic Fabry-Perot Probe

School of Engineering, Nazarbayev University, 53 Kabanbay Batyr, Astana 01000, Kazakhstan
Institute of Image-Guided Surgery (IHU), S/c Ircad, STRASBOURG Cedex, Strasbourg 67091, France
Unit of Measurements and Biomedical Instrumentation, Universita’ Campus Bio-Medico di Roma, via Alvaro del Portillo 21, Roma 00128, Italy
Optical Fibre Sensors Research Centre (OFSRC), University of Limerick, Limerick V94 T9PX, Ireland
Author to whom correspondence should be addressed.
Academic Editor: Manuel Lopez-Amo
Received: 16 March 2016 / Revised: 4 April 2016 / Accepted: 8 April 2016 / Published: 15 April 2016
(This article belongs to the Special Issue Optical Fiber Sensors 2016)
Full-Text   |   PDF [1942 KB, uploaded 15 April 2016]   |  


We report the first-ever intra-tissue pressure measurement performed during 1064 nm laser ablation (LA) of an ex vivo porcine liver. Pressure detection has been performed with a biocompatible, all-glass, temperature-insensitive Extrinsic Fabry-Perot Interferometry (EFPI) miniature probe; the proposed methodology mimics in-vivo treatment. Four experiments have been performed, positioning the probe at different positions from the laser applicator tip (from 0.5 mm to 5 mm). Pressure levels increase during ablation time, and decrease with distance from applicator tip: the recorded peak parenchymal pressure levels range from 1.9 kPa to 71.6 kPa. Different pressure evolutions have been recorded, as pressure rises earlier in proximity of the tip. The present study is the first investigation of parenchymal pressure detection in liver undergoing LA: the successful detection of intra-tissue pressure may be a key asset for improving LA, as pressure levels have been correlated to scattered recurrences of tumors by different studies. View Full-Text
Keywords: fiber optic sensors; pressure measurement; Fabry-Perot; ablation of tissue fiber optic sensors; pressure measurement; Fabry-Perot; ablation of tissue

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Tosi, D.; Saccomandi, P.; Schena, E.; Duraibabu, D.B.; Poeggel, S.; Leen, G.; Lewis, E. Intra-Tissue Pressure Measurement in Ex Vivo Liver Undergoing Laser Ablation with Fiber-Optic Fabry-Perot Probe. Sensors 2016, 16, 544.

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