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Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers

1
State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, China
2
CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, Jiangsu, China
*
Author to whom correspondence should be addressed.
Academic Editor: Sandeep Kumar Vashist
Sensors 2015, 15(12), 31558-31565; https://doi.org/10.3390/s151229877
Received: 4 November 2015 / Revised: 5 December 2015 / Accepted: 11 December 2015 / Published: 15 December 2015
(This article belongs to the Section Biosensors)
We report ultrasensitive and highly selective detection of testosterone based on microring resonance sensor using molecularly imprinted polymers (MIP). A silicon-on-insulator (SOI) micoring resonator was modified by MIP films (MIPs) on a surface. The MIPs was synthesized by thermopolymerization using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as crosslinking agent. The concentration of detected testosterone varies from 0.05 ng/mL to 10 ng/mL. The detection limit reaches 48.7 pg/mL. Ultrahigh sensitivity, good specificity and reproducibility have been demonstrated, indicating the great potential of making a cost effective and easy to operate lab-on-Chip and down scaling micro-fluidics devices in biosensing. View Full-Text
Keywords: Microring resonator; Molecularly imprinted polymers; Testosterone Microring resonator; Molecularly imprinted polymers; Testosterone
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Chen, Y.; Liu, Y.; Shen, X.; Chang, Z.; Tang, L.; Dong, W.-F.; Li, M.; He, J.-J. Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers. Sensors 2015, 15, 31558-31565.

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