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Department of Chemistry, Mangalore University, Mangalagangothri, Mangalore 574 199, Karnataka, India
Author to whom correspondence should be addressed.
Molbank 2019, 2019(2), M1058;
Received: 3 April 2019 / Revised: 24 April 2019 / Accepted: 30 April 2019 / Published: 2 May 2019
(This article belongs to the Special Issue Molecules from Catalytic Processes)
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5-methyl-2-(pyridin-3-yl)-1,3-thiazole-4-carbohydrazide (1) on treatment with 4-fluorobenzaldehyde in presence of catalytic amount of acetic acid, accessed the target compound (2) with the yield of 79%. The target compound was confirmed by 1H-NMR, 13C-NMR, FT-IR and LCMS. In vitro antibacterial activity against Staphylococcus aureus (S. Aureus), Bacillus subtilis (B. subtilis), Escherichia coli (E. coli), and Pseudomonas aeruginosa (P. aeruginosa) were carried out and compound 2 showed promising activity against B. subtilis. In addition, compound 2 was analyzed for DNA binding study. It revealed that compound 2 has a promising affinity towards DNA double helix. View Full-Text
Keywords: thiazole; condensation; antibacterial; DNA binding thiazole; condensation; antibacterial; DNA binding
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Kamat, V.; Santosh, R.; Nayak, S.P. (E)-N′-(4-Fluorobenzylidene)-5-methyl-2-(pyridin-3-yl)thiazole-4-carbohydrazide. Molbank 2019, 2019, M1058.

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