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A Ternary Nickel(II) Schiff Base Complex Containing Di-Anionic and Neutral Forms of a Dithiocarbazate Schiff Base
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Department of Chemistry, Mangalore University, Mangalagangothri, Mangalore 574 199, Karnataka, India
Author to whom correspondence should be addressed.
Molbank 2019, 2019(2), M1058;
Received: 3 April 2019 / Revised: 24 April 2019 / Accepted: 30 April 2019 / Published: 2 May 2019
(This article belongs to the Collection Molecules from Catalytic Processes)
5-methyl-2-(pyridin-3-yl)-1,3-thiazole-4-carbohydrazide (1) on treatment with 4-fluorobenzaldehyde in presence of catalytic amount of acetic acid, accessed the target compound (2) with the yield of 79%. The target compound was confirmed by 1H-NMR, 13C-NMR, FT-IR and LCMS. In vitro antibacterial activity against Staphylococcus aureus (S. Aureus), Bacillus subtilis (B. subtilis), Escherichia coli (E. coli), and Pseudomonas aeruginosa (P. aeruginosa) were carried out and compound 2 showed promising activity against B. subtilis. In addition, compound 2 was analyzed for DNA binding study. It revealed that compound 2 has a promising affinity towards DNA double helix. View Full-Text
Keywords: thiazole; condensation; antibacterial; DNA binding thiazole; condensation; antibacterial; DNA binding
MDPI and ACS Style

Kamat, V.; Santosh, R.; Nayak, S.P. (E)-N′-(4-Fluorobenzylidene)-5-methyl-2-(pyridin-3-yl)thiazole-4-carbohydrazide. Molbank 2019, 2019, M1058.

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