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Molbank 2018, 2018(1), M973;

Synthesis of All Stereoisomers of 1-(4-Methoxyphenyl)-2,3,4,9-tetrahydro-N-methyl-1H-pyrido[3,4-b]indole-3-carboxamide

Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan
Author to whom correspondence should be addressed.
Received: 6 December 2017 / Revised: 6 January 2018 / Accepted: 8 January 2018 / Published: 10 January 2018
(This article belongs to the Section Organic Synthesis)
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In this study, all four stereoisomers of tryptoline or tetrahydro-β-carboline were synthesized in high yields by the catalyst-free amidation of methyl ester using methylamine under mild conditions. All isomers of the obtained amide and the precursor methyl ester were subjected to cell viability measurements on HeLa cells. The results indicated that the stereochemistry of the derivatives is clearly related to cell viability. View Full-Text
Keywords: tryptoline; β-carboline; amidation; cytotoxicity tryptoline; β-carboline; amidation; cytotoxicity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Onda, M.; Higashida, A.; Hirano, T.; Nishio, T.; Hakamata, W. Synthesis of All Stereoisomers of 1-(4-Methoxyphenyl)-2,3,4,9-tetrahydro-N-methyl-1H-pyrido[3,4-b]indole-3-carboxamide. Molbank 2018, 2018, M973.

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