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Article

A Soy-Derived Isoflavone Genistein Inhibits the Life Cycle of PRRSV In Vitro

by
Dan Cao
1,
Changchao Huan
2,3,4,
Xiaofei Tang
1 and
Yongguo Xue
1,*
1
Soybean Research Institute, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, China
2
Institute of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China
3
Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China
4
Key Laboratory of Avian Bioproduct Development, Ministry of Agriculture and Rural Affairs, Yangzhou 225009, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2026, 27(18), 8235; https://doi.org/10.3390/ijms27188235
Submission received: 10 July 2026 / Revised: 8 September 2026 / Accepted: 12 September 2026 / Published: 16 September 2026
(This article belongs to the Special Issue Bioactive Compounds of Natural Origin: 2nd Edition)
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Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) has become a global health threat for swine. Because of the limited effectiveness of commercial vaccine strategies and the absence of specific antiviral chemical drugs for PRRS, it is urgent to identify new strategies for preventing and controlling PRRSV infections. Genistein, a soy-derived isoflavone, has shown promise in reducing viremia in PRRSV-infected pigs. However, its antiviral molecular mechanism remains unclear. This study investigates the inhibitory effects and mechanism of genistein on PRRSV infection in vitro. Our results demonstrated that genistein dose-dependently inhibited PRRSV infection in Marc-145 cells at several stages of the PRRSV replication cycle. With its favorable safety profile and potent efficacy in antiviral and growth promotion in swine, genistein stands out as a promising dietary adjunct for PRRSV prevention and control in swine husbandry.
Keywords: Soybean; genistein; PRRSV; antiviral mechanism; autophagy Soybean; genistein; PRRSV; antiviral mechanism; autophagy

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MDPI and ACS Style

Cao, D.; Huan, C.; Tang, X.; Xue, Y. A Soy-Derived Isoflavone Genistein Inhibits the Life Cycle of PRRSV In Vitro. Int. J. Mol. Sci. 2026, 27, 8235. https://doi.org/10.3390/ijms27188235

AMA Style

Cao D, Huan C, Tang X, Xue Y. A Soy-Derived Isoflavone Genistein Inhibits the Life Cycle of PRRSV In Vitro. International Journal of Molecular Sciences. 2026; 27(18):8235. https://doi.org/10.3390/ijms27188235

Chicago/Turabian Style

Cao, Dan, Changchao Huan, Xiaofei Tang, and Yongguo Xue. 2026. "A Soy-Derived Isoflavone Genistein Inhibits the Life Cycle of PRRSV In Vitro" International Journal of Molecular Sciences 27, no. 18: 8235. https://doi.org/10.3390/ijms27188235

APA Style

Cao, D., Huan, C., Tang, X., & Xue, Y. (2026). A Soy-Derived Isoflavone Genistein Inhibits the Life Cycle of PRRSV In Vitro. International Journal of Molecular Sciences, 27(18), 8235. https://doi.org/10.3390/ijms27188235

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