Correction: Salinas-Giegé et al. tRNA Biology in Mitochondria. Int. J. Mol. Sci. 2015, 16, 4518–4559

There was an error in the original publication [1]. The sentence “Similarly, in the moss P. patens, cytosolic tRNA^Arg(ACG) is imported in mitochondria where it undergoes an A to I editing at the wobble position of the anticodon [193]” on Paragraph 2 of Section 4.3.2 is incorrect.

A correction has been made to Section 4 ‘Biogenesis of Functional Mitochondrial tRNAs’, Section 4.3 ‘Functions and Mechanisms for tRNA Modifications and Editing’, Section 4.3.2 ‘Mitochondrial tRNA Editing’, Paragraph 2:

Beyond the mitochondrial encoded tRNAs, editing processes were also reported for cytosolic tRNAs imported into mitochondria. For instance, it was shown in L. tarentolae that a specific C to U editing in the anticodon of the imported nonedited tRNA^Trp allows the decoding of mitochondrial UGA codons as tryptophans [192]. In contrast, in the moss P. patens a tRNA^Arg(ACG) isoacceptor encoded in mitochondria, thus not imported from the cytosol, is deaminated at position A34 to obtain an ICG anticodon [193]. Interestingly for protozoan tRNA^Trp, import and editing have drastic structural consequences, since this tRNA is partially thiolated at universally conserved position 33 to s²U33 and O′-methylated at the ribose moiety of Ψ32 as well as on edited U34 and nonedited C34 [194]. The presence of s²U33 and the concentration of O′-methylated pyrimidines in the anticodon domain, likely is the prerequisite for proper decoding of the Trp codon by conferring conformation rigidity and chemical stability to the anticodon loop. In contrast, dethiolation of cmm⁵s²U within mitochondria at wobble position 34 of imported trypanosomatid tRNAs, as explicitly shown for T. brucei tRNA^Glu, is an alternate editing mechanisms required to modulate decoding [195].

The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.