Next Article in Journal
Impact of Octenyl Succinylation and Bee Products on Maize Starch Films and Apple Storage Quality
Previous Article in Journal
Cardiovascular Disease in the Context of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Comprehensive Narrative Review
Previous Article in Special Issue
Swiss Cheese Gene Is Important for Intestinal Barrier, Microbiome, and Lipid Metabolism Regulation in Drosophila Gut
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 26
Issue 23
10.3390/ijms262311276
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

The Gene Encoding the RCC1 (Regulator of Chromosome Condensation 1) Protein in Drosophila melanogaster and Homo sapiens

by
Vera A. Turtapkina
,
Maria V. Maltseva
,
Elena V. Evtushenko
,
Sima S. Gatzkaya
,
Evgeniya S. Omelina
,
Nadezhda V. Battulina
,
Natalia A. Lemskaya
,
Victor V. Shloma
,
Alexander V. Vershinin
,
Tatyana Yu. Vatolina
and
Igor F. Zhimulev
*
Institute of Molecular and Cellular Biology, Novosibirsk 630090, Russia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2025, 26(23), 11276; https://doi.org/10.3390/ijms262311276
Submission received: 6 September 2025 / Revised: 11 November 2025 / Accepted: 18 November 2025 / Published: 21 November 2025
(This article belongs to the Special Issue Drosophila: A Versatile Model in Biology and Medicine—2nd Edition)
Versions Notes

Abstract

The RCC1 gene is active in ensuring many cellular functions related to cell division in Drosophila melanogaster and Homo sapiens. A detailed comparison of the structure and functions of the RCC1 gene in Drosophila melanogaster and Homo sapiens was carried out using different analytical techniques (bioinformatics, immunofluorescence and confocal microscopy, FISH, and molecular genetic methods). The Drosophila RCC1 gene belongs to the family of housekeeping genes, since it resides in the interbands and gray bands of polytene chromosomes within aquamarine/lazurite chromatin in D. melanogaster. Furthermore, the databases demonstrate that RCC1 in D. melanogaster is expressed in all the tissues at all the developmental stages. According to The Human Protein Atlas, RCC1 in humans also exhibits low tissue specificity for 29 tissues. Immunostaining of polytene chromosomes with RCC1 antibodies revealed approximately 260 sites of RCC1 protein localization exclusively in black bands (sites of developmental genes) and in heterochromatin. The size of the coding gene portions is almost identical for D. melanogaster and H. sapiens, being ~2 kb. The group of Drosophila proteins related to condensed chromatin, RCC1 being a member of this group, has homologs forming similar interaction networks in humans. The conserved nature of the RCC1 gene has been confirmed by cell cycle studies in both species. It was found that expression of the RCC1 gene is upregulated in glioblastoma; the RCC1 protein predominantly resides on centrioles during metaphase.
Keywords: RCC1 gene; cell cycle; RAN; Drosophila melanogaster; Homo sapiens; glioma; gene structure; developmental genes; housekeeping genes RCC1 gene; cell cycle; RAN; Drosophila melanogaster; Homo sapiens; glioma; gene structure; developmental genes; housekeeping genes

Share and Cite

MDPI and ACS Style

Turtapkina, V.A.; Maltseva, M.V.; Evtushenko, E.V.; Gatzkaya, S.S.; Omelina, E.S.; Battulina, N.V.; Lemskaya, N.A.; Shloma, V.V.; Vershinin, A.V.; Vatolina, T.Y.; et al. The Gene Encoding the RCC1 (Regulator of Chromosome Condensation 1) Protein in Drosophila melanogaster and Homo sapiens. Int. J. Mol. Sci. 2025, 26, 11276. https://doi.org/10.3390/ijms262311276

AMA Style

Turtapkina VA, Maltseva MV, Evtushenko EV, Gatzkaya SS, Omelina ES, Battulina NV, Lemskaya NA, Shloma VV, Vershinin AV, Vatolina TY, et al. The Gene Encoding the RCC1 (Regulator of Chromosome Condensation 1) Protein in Drosophila melanogaster and Homo sapiens. International Journal of Molecular Sciences. 2025; 26(23):11276. https://doi.org/10.3390/ijms262311276

Chicago/Turabian Style

Turtapkina, Vera A., Maria V. Maltseva, Elena V. Evtushenko, Sima S. Gatzkaya, Evgeniya S. Omelina, Nadezhda V. Battulina, Natalia A. Lemskaya, Victor V. Shloma, Alexander V. Vershinin, Tatyana Yu. Vatolina, and et al. 2025. "The Gene Encoding the RCC1 (Regulator of Chromosome Condensation 1) Protein in Drosophila melanogaster and Homo sapiens" International Journal of Molecular Sciences 26, no. 23: 11276. https://doi.org/10.3390/ijms262311276

APA Style

Turtapkina, V. A., Maltseva, M. V., Evtushenko, E. V., Gatzkaya, S. S., Omelina, E. S., Battulina, N. V., Lemskaya, N. A., Shloma, V. V., Vershinin, A. V., Vatolina, T. Y., & Zhimulev, I. F. (2025). The Gene Encoding the RCC1 (Regulator of Chromosome Condensation 1) Protein in Drosophila melanogaster and Homo sapiens. International Journal of Molecular Sciences, 26(23), 11276. https://doi.org/10.3390/ijms262311276

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Article metric data becomes available approximately 24 hours after publication online.
Back to TopTop