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Review

Natural Sulfur Compounds in Mineral Waters: Implications for Human Health and Disease

1
Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, Perth, WA 6845, Australia
2
Curtin Medical Research Institute (Curtin-MRI), Faculty of Health Sciences, Curtin University, Bentley, Perth, WA 6845, Australia
3
Department of Environmental Science and Prevention, University of Ferrara, 43121 Ferrara, Italy
4
Faculty of Medicine and Surgery, Vita-Salute University—San Raffaele, 20132 Milan, Italy
5
Foundation for Scientific Research in Balneology (FoRST), 00198 Rome, Italy
6
Department of Medicine and Surgery (DiMeC), University of Parma, 43100 Parma, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2025, 26(21), 10807; https://doi.org/10.3390/ijms262110807
Submission received: 23 September 2025 / Revised: 4 November 2025 / Accepted: 4 November 2025 / Published: 6 November 2025

Abstract

Natural sulfur compounds found in various mineral spring waters have attracted considerable interest due to their possible health benefits and healing qualities. Key substances such as hydrogen sulfide (H2S), sulfate (SO42−), and thiosulfate (S2O32−) are essential to numerous physiological functions. This overview delves into the biochemical pathways through which these sulfur compounds exert their influence, emphasizing their roles as antioxidants, anti-inflammatories, and detoxifying agents. Furthermore, it investigates the therapeutic promise of mineral waters rich in sulfur for various diseases like arthritis, skin ailments, and heart diseases. Emerging studies indicate that regular use or topical application of these waters could enhance health outcomes and aid in the prevention of a multitude of diseases. Nonetheless, additional research is required to clarify sulfur water’s mechanisms of action and to develop standardized protocols for their therapeutic applications. This descriptive review highlights the significance of integrating natural sulfur compounds into comprehensive health strategies and advocates for ongoing investigation into their advantages in medical contexts.
Keywords: spa therapy; balneotherapy; thermal medicine; sulfur compounds; mineral water; spa water spa therapy; balneotherapy; thermal medicine; sulfur compounds; mineral water; spa water

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MDPI and ACS Style

Vaccarezza, M.; Vitale, M.; Falletta, P.; di Martino, O. Natural Sulfur Compounds in Mineral Waters: Implications for Human Health and Disease. Int. J. Mol. Sci. 2025, 26, 10807. https://doi.org/10.3390/ijms262110807

AMA Style

Vaccarezza M, Vitale M, Falletta P, di Martino O. Natural Sulfur Compounds in Mineral Waters: Implications for Human Health and Disease. International Journal of Molecular Sciences. 2025; 26(21):10807. https://doi.org/10.3390/ijms262110807

Chicago/Turabian Style

Vaccarezza, Mauro, Marco Vitale, Paola Falletta, and Orsola di Martino. 2025. "Natural Sulfur Compounds in Mineral Waters: Implications for Human Health and Disease" International Journal of Molecular Sciences 26, no. 21: 10807. https://doi.org/10.3390/ijms262110807

APA Style

Vaccarezza, M., Vitale, M., Falletta, P., & di Martino, O. (2025). Natural Sulfur Compounds in Mineral Waters: Implications for Human Health and Disease. International Journal of Molecular Sciences, 26(21), 10807. https://doi.org/10.3390/ijms262110807

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