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Communication

Is There a Link between Thyroid Peroxidase Gene Promoter Polymorphisms and Autoimmune Thyroiditis in the Polish Population?

by
Katarzyna Lacka
1,*,†,
Adam Maciejewski
1,†,
Piotr Jarecki
2,
Waldemar Herman
3,
Jan K. Lacki
4,5,
Ryszard Żaba
6 and
Michał J. Kowalczyk
6
1
Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 60-355 Poznan, Poland
2
General Practitioner Unit, 67-400 Wschowa, Poland
3
Outpatients Unit for Endocrine Diseases, 67-400 Wschowa, Poland
4
Department of Medicine, The Jacob of Paradies University, 66-400 Gorzow Wielkopolski, Poland
5
Department of Internal Medicine, Collegium Medicum, University of Zielona Gora, 65-417 Zielona Gora, Poland
6
Department of Dermatology and Venereology, Poznan University of Medical Sciences, 60-355 Poznan, Poland
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2024, 25(6), 3312; https://doi.org/10.3390/ijms25063312
Submission received: 7 February 2024 / Revised: 10 March 2024 / Accepted: 12 March 2024 / Published: 14 March 2024
(This article belongs to the Special Issue Advances in Molecular Research on Autoimmune Diseases)
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Abstract

(1) Autoimmune thyroiditis (AIT) is the most common cause of primary hypothyroidism and one of the most frequent organ-specific autoimmune diseases. Its pathogenesis is polygenic and still requires further research. The aim of the study was to assess, for the first time in the Caucasian population, the role of selected TPO gene promoter polymorphisms (rs2071399 G/A, rs2071400C/T, rs2071402 A/G, and rs2071403 A/G) in the development of AIT. A total of 237 patients diagnosed with AIT and 130 healthy controls were genotyped for four TPO gene polymorphisms, and the results were statistically analyzed to check for the role of these polymorphisms. There were no significant differences in the genotype and allele frequencies of the studied TPO gene promoter polymorphisms between patients and controls (p > 0.05). The haplotype distribution (rs2071400–rs2071402–rs2071403) between the two studied groups was similar for the most common variants (CGA, CAG, TGG). Only a rare haplotype (CGG) occurred more frequently among patients compared to controls (p = 0.04). The studied TPO gene promoter polymorphisms did not show an association with susceptibility to AIT in the Caucasian Polish population, contrary to the results in Japanese patients.
Keywords: autoimmune thyroiditis; thyroid peroxidase; polymorphism; autoantibodies; TPOAb; autoimmunity autoimmune thyroiditis; thyroid peroxidase; polymorphism; autoantibodies; TPOAb; autoimmunity

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MDPI and ACS Style

Lacka, K.; Maciejewski, A.; Jarecki, P.; Herman, W.; Lacki, J.K.; Żaba, R.; Kowalczyk, M.J. Is There a Link between Thyroid Peroxidase Gene Promoter Polymorphisms and Autoimmune Thyroiditis in the Polish Population? Int. J. Mol. Sci. 2024, 25, 3312. https://doi.org/10.3390/ijms25063312

AMA Style

Lacka K, Maciejewski A, Jarecki P, Herman W, Lacki JK, Żaba R, Kowalczyk MJ. Is There a Link between Thyroid Peroxidase Gene Promoter Polymorphisms and Autoimmune Thyroiditis in the Polish Population? International Journal of Molecular Sciences. 2024; 25(6):3312. https://doi.org/10.3390/ijms25063312

Chicago/Turabian Style

Lacka, Katarzyna, Adam Maciejewski, Piotr Jarecki, Waldemar Herman, Jan K. Lacki, Ryszard Żaba, and Michał J. Kowalczyk. 2024. "Is There a Link between Thyroid Peroxidase Gene Promoter Polymorphisms and Autoimmune Thyroiditis in the Polish Population?" International Journal of Molecular Sciences 25, no. 6: 3312. https://doi.org/10.3390/ijms25063312

APA Style

Lacka, K., Maciejewski, A., Jarecki, P., Herman, W., Lacki, J. K., Żaba, R., & Kowalczyk, M. J. (2024). Is There a Link between Thyroid Peroxidase Gene Promoter Polymorphisms and Autoimmune Thyroiditis in the Polish Population? International Journal of Molecular Sciences, 25(6), 3312. https://doi.org/10.3390/ijms25063312

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