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Volume 25
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10.3390/ijms25179290
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Article

Impact of Alcalase Hydrolysis and Simulated Gastrointestinal Digestion on the Release of Bioactive Peptides from Erythrina edulis (Chachafruto) Proteins

by
Jessica L. Correa
1,
José Edgar Zapata
1 and
Blanca Hernández-Ledesma
2,*
1
Nutrition and Food Technology Group, Universidad de Antioquia, Medellin 050010, Colombia
2
Development and Innovation in Alternative Proteins Group (INNOVAPROT), Institute of Food Science Research (CIAL, CSIC-UAM, CEI UAM + CSIC), Nicolás Cabrera, 28049 Madrid, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(17), 9290; https://doi.org/10.3390/ijms25179290
Submission received: 4 July 2024 / Revised: 28 July 2024 / Accepted: 25 August 2024 / Published: 27 August 2024
(This article belongs to the Collection Feature Papers in Bioactives and Nutraceuticals)
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Abstract

Amidst increasing awareness of diet-health relationships, plant-derived bioactive peptides are recognized for their dual nutritional and health benefits. This study investigates bioactive peptides released after Alcalase hydrolysis of protein from chachafruto (Erythrina edulis), a nutrient-rich South American leguminous plant, focusing on their behavior during simulated gastrointestinal digestion. Evaluating their ability to scavenge radicals, mitigate oxidative stress, and influence immune response biomarkers, this study underscores the importance of understanding peptide interactions in digestion. The greatest contribution to the antioxidant activity was exerted by the low molecular weight peptides with ORAC values for the <3 kDa fraction of HES, GD-HES, and GID-HES of 0.74 ± 0.03, 0.72 ± 0.004, and 0.56 ± 0.01 (μmol TE/mg protein, respectively). GD-HES and GID-HES exhibited immunomodulatory effects, promoting the release of NO up to 18.52 and 8.58 µM, respectively. The findings of this study highlighted the potential of chachafruto bioactive peptides in functional foods and nutraceuticals, supporting human health through dietary interventions.
Keywords: Erythrina edulis; enzymatic hydrolysis; in vitro gastrointestinal digestion; peptides; antioxidant; macrophages Erythrina edulis; enzymatic hydrolysis; in vitro gastrointestinal digestion; peptides; antioxidant; macrophages

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MDPI and ACS Style

Correa, J.L.; Zapata, J.E.; Hernández-Ledesma, B. Impact of Alcalase Hydrolysis and Simulated Gastrointestinal Digestion on the Release of Bioactive Peptides from Erythrina edulis (Chachafruto) Proteins. Int. J. Mol. Sci. 2024, 25, 9290. https://doi.org/10.3390/ijms25179290

AMA Style

Correa JL, Zapata JE, Hernández-Ledesma B. Impact of Alcalase Hydrolysis and Simulated Gastrointestinal Digestion on the Release of Bioactive Peptides from Erythrina edulis (Chachafruto) Proteins. International Journal of Molecular Sciences. 2024; 25(17):9290. https://doi.org/10.3390/ijms25179290

Chicago/Turabian Style

Correa, Jessica L., José Edgar Zapata, and Blanca Hernández-Ledesma. 2024. "Impact of Alcalase Hydrolysis and Simulated Gastrointestinal Digestion on the Release of Bioactive Peptides from Erythrina edulis (Chachafruto) Proteins" International Journal of Molecular Sciences 25, no. 17: 9290. https://doi.org/10.3390/ijms25179290

APA Style

Correa, J. L., Zapata, J. E., & Hernández-Ledesma, B. (2024). Impact of Alcalase Hydrolysis and Simulated Gastrointestinal Digestion on the Release of Bioactive Peptides from Erythrina edulis (Chachafruto) Proteins. International Journal of Molecular Sciences, 25(17), 9290. https://doi.org/10.3390/ijms25179290

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