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Article

Differential Cytokine Responses and the Clinical Severity of Adult and Pediatric Nephropathia Epidemica

by
Ekaterina Martynova
1,†,
Robert J. Stott-Marshall
2,†,
Venera Shakirova
3,
Albina Saubanova
3,
Asiya Bulatova
3,
Yuriy N. Davidyuk
1,
Emmanuel Kabwe
1,
Maria Markelova
1,
Ilseyar Khaertynova
3,
Toshana L. Foster
2,* and
Svetlana Khaiboullina
1,*
1
“Gene and Cell Technologies” Institute of Fundamental Medicine and Biology, Kazan Federal University, OpenLab, 420008 Kazan, Russia
2
Faculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK
3
State Medical Academy, 420012 Kazan, Russia
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2023, 24(8), 7016; https://doi.org/10.3390/ijms24087016
Submission received: 28 December 2022 / Revised: 1 March 2023 / Accepted: 17 March 2023 / Published: 10 April 2023
(This article belongs to the Collection Feature Papers in Molecular Pathology, Diagnostics, and Therapeutics)
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Abstract

Nephropathia epidemica (NE), caused by the hantavirus infection, is endemic in Tatarstan Russia. The majority of patients are adults, with infection rarely diagnosed in children. This limited number of pediatric NE cases means there is an inadequate understanding of disease pathogenesis in this age category. Here, we have analyzed clinical and laboratory data in adults and children with NE to establish whether and how the disease severity differs between the two age groups. Serum cytokines were analyzed in samples collected from 11 children and 129 adult NE patients during an outbreak in 2019. A kidney toxicity panel was also used to analyze urine samples from these patients. Additionally, serum and urine samples were analyzed from 11 control children and 26 control adults. Analysis of clinical and laboratory data revealed that NE was milder in children than in adults. A variation in serum cytokine activation could explain the differences in clinical presentation. Cytokines associated with activation of Th1 lymphocytes were prominent in adults, while they were obscured in sera from pediatric NE patients. In addition, a prolonged activation of kidney injury markers was found in adults with NE, whilst only a short-lasting activation of these markers was observed in children with NE. These findings support previous observations of age differences in NE severity, which should be considered when diagnosing the disease in children.
Keywords: nephropathia epidemica; cytokine; pediatric nephropathia epidemica; cytokine; pediatric

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MDPI and ACS Style

Martynova, E.; Stott-Marshall, R.J.; Shakirova, V.; Saubanova, A.; Bulatova, A.; Davidyuk, Y.N.; Kabwe, E.; Markelova, M.; Khaertynova, I.; Foster, T.L.; et al. Differential Cytokine Responses and the Clinical Severity of Adult and Pediatric Nephropathia Epidemica. Int. J. Mol. Sci. 2023, 24, 7016. https://doi.org/10.3390/ijms24087016

AMA Style

Martynova E, Stott-Marshall RJ, Shakirova V, Saubanova A, Bulatova A, Davidyuk YN, Kabwe E, Markelova M, Khaertynova I, Foster TL, et al. Differential Cytokine Responses and the Clinical Severity of Adult and Pediatric Nephropathia Epidemica. International Journal of Molecular Sciences. 2023; 24(8):7016. https://doi.org/10.3390/ijms24087016

Chicago/Turabian Style

Martynova, Ekaterina, Robert J. Stott-Marshall, Venera Shakirova, Albina Saubanova, Asiya Bulatova, Yuriy N. Davidyuk, Emmanuel Kabwe, Maria Markelova, Ilseyar Khaertynova, Toshana L. Foster, and et al. 2023. "Differential Cytokine Responses and the Clinical Severity of Adult and Pediatric Nephropathia Epidemica" International Journal of Molecular Sciences 24, no. 8: 7016. https://doi.org/10.3390/ijms24087016

APA Style

Martynova, E., Stott-Marshall, R. J., Shakirova, V., Saubanova, A., Bulatova, A., Davidyuk, Y. N., Kabwe, E., Markelova, M., Khaertynova, I., Foster, T. L., & Khaiboullina, S. (2023). Differential Cytokine Responses and the Clinical Severity of Adult and Pediatric Nephropathia Epidemica. International Journal of Molecular Sciences, 24(8), 7016. https://doi.org/10.3390/ijms24087016

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