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Review

Impact of Pesticide Residues on the Gut-Microbiota–Blood–Brain Barrier Axis: A Narrative Review

by
Maria Abou Diwan
1,2,
Marwa Lahimer
1,
Véronique Bach
1,
Fabien Gosselet
2,
Hafida Khorsi-Cauet
1,† and
Pietra Candela
2,*,†
1
PERITOX—Périnatalité et Risques Toxiques—UMR_I 01, Centre Universitaire de Recherche en Santé, CURS-UPJV, University of Picardy Jules Verne, CEDEX 1, 80054 Amiens, France
2
Laboratoire de la Barrière Hémato-Encéphalique (LBHE), UR 2465, University of Artois, 62300 Lens, France
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2023, 24(7), 6147; https://doi.org/10.3390/ijms24076147
Submission received: 6 March 2023 / Revised: 17 March 2023 / Accepted: 20 March 2023 / Published: 24 March 2023
(This article belongs to the Special Issue Mechanisms and Interventions for Neurological and Psychological Disorders 2.0)
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Abstract

Accumulating evidence indicates that chronic exposure to a low level of pesticides found in diet affects the human gut-microbiota–blood–brain barrier (BBB) axis. This axis describes the physiological and bidirectional connection between the microbiota, the intestinal barrier (IB), and the BBB. Preclinical observations reported a gut microbial alteration induced by pesticides, also known as dysbiosis, a condition associated not only with gastrointestinal disorders but also with diseases affecting other distal organs, such as the BBB. However, the interplay between pesticides, microbiota, the IB, and the BBB is still not fully explored. In this review, we first consider the similarities/differences between these two physiological barriers and the different pathways that link the gut microbiota and the BBB to better understand the dialogue between bacteria and the brain. We then discuss the effects of chronic oral pesticide exposure on the gut-microbiota-BBB axis and raise awareness of the danger of chronic exposure, especially during the perinatal period (pregnant women and offspring).
Keywords: gut-microbiota-BBB axis; barriers; pesticides; Chlorpyrifos; prebiotics; vulnerable population gut-microbiota-BBB axis; barriers; pesticides; Chlorpyrifos; prebiotics; vulnerable population

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MDPI and ACS Style

Abou Diwan, M.; Lahimer, M.; Bach, V.; Gosselet, F.; Khorsi-Cauet, H.; Candela, P. Impact of Pesticide Residues on the Gut-Microbiota–Blood–Brain Barrier Axis: A Narrative Review. Int. J. Mol. Sci. 2023, 24, 6147. https://doi.org/10.3390/ijms24076147

AMA Style

Abou Diwan M, Lahimer M, Bach V, Gosselet F, Khorsi-Cauet H, Candela P. Impact of Pesticide Residues on the Gut-Microbiota–Blood–Brain Barrier Axis: A Narrative Review. International Journal of Molecular Sciences. 2023; 24(7):6147. https://doi.org/10.3390/ijms24076147

Chicago/Turabian Style

Abou Diwan, Maria, Marwa Lahimer, Véronique Bach, Fabien Gosselet, Hafida Khorsi-Cauet, and Pietra Candela. 2023. "Impact of Pesticide Residues on the Gut-Microbiota–Blood–Brain Barrier Axis: A Narrative Review" International Journal of Molecular Sciences 24, no. 7: 6147. https://doi.org/10.3390/ijms24076147

APA Style

Abou Diwan, M., Lahimer, M., Bach, V., Gosselet, F., Khorsi-Cauet, H., & Candela, P. (2023). Impact of Pesticide Residues on the Gut-Microbiota–Blood–Brain Barrier Axis: A Narrative Review. International Journal of Molecular Sciences, 24(7), 6147. https://doi.org/10.3390/ijms24076147

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