Association between NLRP3 rs10754558 and CARD8 rs2043211 Variants and Susceptibility to Chronic Kidney Disease
Abstract
:1. Introduction
2. Results
2.1. Clinical Characteristics of Cases and Control Subjects
2.2. Association of NLRP3 and CARD8 Gene Polymorphisms with CKD and ESRD
2.3. CRP Levels According to Genotype
3. Discussion
4. Materials and Methods
4.1. Study Population
4.2. SNP Genotyping
4.3. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Controls (n = 85) | Cases (n = 303) | p | |
---|---|---|---|
Age (years) | 72.06 ± 6.19 | 62.10 ± 14.88 | <0.001 |
Sex (males) | 51 (60.00) | 199 (65.68) | 0.402 |
Glucose (mg/dL) | 109.06 ± 39.61 | 105.45 ± 38.44 | 0.455 |
Urea (mg/dL) | 32.46 ± 9.43 | 54.84 ± 30.60 | <0.001 |
Uric Acid (mg/dL) | 4.63 ± 1.39 | 5.92 ± 1.50 | <0.001 |
Ca (mg/dL) | 9.45 ± 0.50 | 9.43 ± 0.83 | 0.845 |
Ph (mg/dL) | 3.39 ± 0.58 | 4.01 ± 1.52 | <0.001 |
Total Cholesterol (mg/dL) | 206.38 ± 39.88 | 180.69 ± 48.39 | <0.001 |
Triglycerides (mg/dL) | 131.44 ± 65.74 | 176.66 ± 101.63 | <0.001 |
HDL Cholesterol (mg/dL) | 59.02 ± 16.37 | 49.51 ± 17.60 | <0.001 |
LDL Cholesterol (mg/dL) | 121.04 ± 34.21 | 95.22 ± 40.24 | <0.001 |
Ferritinemy (ng/mL) | 72.00 (42.00–161.00) | 135.00 (45.50–391.50) | <0.001 |
CRP (mg/L) | 2.46 (1.56–4.79) | 5.18 (1.10–12.23) | 0.01 |
Serum Albumin (gr/dL) | 3.95 ± 0.32 | 3.72 ± 0.62 | <0.001 |
Hgb (gr/dL) | 14.21 ± 1.54 | 12.37 ± 1.90 | <0.001 |
Type 2 Diabetes | 13 (15.29) | 63(20.79) | 0.330 |
Hypertension | 49 (57.65) | 209 (68.98) | 0.068 |
Controls (n = 85) | Cases (n = 303) | AOR (95% CI) | p | |
---|---|---|---|---|
NLRP3 rs10754558 | ||||
CC | 39 (45.88) | 77 (25.41) | 1 | |
CG | 31 (36.47) | 44 (14.52) | 0.64 (0.32–1.24) | 0.18 |
GG | 15 (17.65) | 182 (60.07) | 6.04 (3.05–12.53) | <0.001 |
C allele | 109 (64.12) | 198 (32.67%) | 1 | |
G allele | 61 (35.88) | 408 (67.33%) | 3.56 (2.43–5.26) | <0.001 |
CARD8 rs2043211 | ||||
AA | 44 (51.76) | 39 (12.87) | 1 | |
TA | 29 (34.12) | 99 (32.67) | 4.41 (2.29–8.71) | <0.001 |
TT | 12 (14.12) | 165 (54.46) | 14.34 (6.80–32.28) | <0.001 |
A allele | 117 (68.82) | 177 (29.21%) | 1 | |
T allele | 53 (31.18) | 429 (70.79%) | 5.06 (3.42–7.57) | <0.001 |
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La Russa, A.; Lofaro, D.; Montesanto, A.; La Russa, D.; Zaza, G.; Granata, S.; Di Dio, M.; Serra, R.; Andreucci, M.; Bonofiglio, R.; et al. Association between NLRP3 rs10754558 and CARD8 rs2043211 Variants and Susceptibility to Chronic Kidney Disease. Int. J. Mol. Sci. 2023, 24, 4184. https://doi.org/10.3390/ijms24044184
La Russa A, Lofaro D, Montesanto A, La Russa D, Zaza G, Granata S, Di Dio M, Serra R, Andreucci M, Bonofiglio R, et al. Association between NLRP3 rs10754558 and CARD8 rs2043211 Variants and Susceptibility to Chronic Kidney Disease. International Journal of Molecular Sciences. 2023; 24(4):4184. https://doi.org/10.3390/ijms24044184
Chicago/Turabian StyleLa Russa, Antonella, Danilo Lofaro, Alberto Montesanto, Daniele La Russa, Gianluigi Zaza, Simona Granata, Michele Di Dio, Raffaele Serra, Michele Andreucci, Renzo Bonofiglio, and et al. 2023. "Association between NLRP3 rs10754558 and CARD8 rs2043211 Variants and Susceptibility to Chronic Kidney Disease" International Journal of Molecular Sciences 24, no. 4: 4184. https://doi.org/10.3390/ijms24044184