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Article

Aquaporin-4 Expression Switches from White to Gray Matter Regions during Postnatal Development of the Central Nervous System

by
Francisco Mayo
1,2,
Lourdes González-Vinceiro
1,2,
Laura Hiraldo-González
1,2,
Claudia Calle-Castillejo
1,
Sara Morales-Alvarez
1,
Reposo Ramírez-Lorca
1,2 and
Miriam Echevarría
1,2,*
1
Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, (HUVR)/Spanish National Research Council (CSIC)/University of Seville, 41013 Seville, Spain
2
Department of Physiology and Biophysics, University of Seville, 41009 Seville, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(3), 3048; https://doi.org/10.3390/ijms24033048
Submission received: 4 January 2023 / Revised: 24 January 2023 / Accepted: 31 January 2023 / Published: 3 February 2023
(This article belongs to the Special Issue Aquaporins in Brain Disease)
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Abstract

Aquaporin-4 (AQP4) is the most abundant water channel in the central nervous system and plays a fundamental role in maintaining water homeostasis there. In adult mice, AQP4 is located mainly in ependymal cells, in the endfeet of perivascular astrocytes, and in the glia limitans. Meanwhile, its expression, location, and function throughout postnatal development remain largely unknown. Here, the expression of AQP4 mRNA was studied by in situ hybridization and RT-qPCR, and the localization and amount of protein was studied by immunofluorescence and western blotting, both in the brain and spinal cord. For this, wild-type mice of the C57BL/6 line, aged 1, 3, 7, 11, 20, and 60 days, and 18 months were used. The results showed a change in both the expression and location of AQP4 in postnatal development compared to those during adult life. In the early stages of postnatal development it appears in highly myelinated areas, such as the corpus callosum or cerebellum, and as the animal grows, it disappears from these areas, passing through the cortical regions of the forebrain and concentrating around the blood vessels. These findings suggest an unprecedented possible role for AQP4 in the early cell differentiation process, during the first days of life in the newborn animal, which will lead to myelination.
Keywords: aquaporins; AQP4; central nervous system (CNS); gray matter; white matter; oligodendrocytes; astrocytes; oligodendrogenesis; myelination aquaporins; AQP4; central nervous system (CNS); gray matter; white matter; oligodendrocytes; astrocytes; oligodendrogenesis; myelination

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MDPI and ACS Style

Mayo, F.; González-Vinceiro, L.; Hiraldo-González, L.; Calle-Castillejo, C.; Morales-Alvarez, S.; Ramírez-Lorca, R.; Echevarría, M. Aquaporin-4 Expression Switches from White to Gray Matter Regions during Postnatal Development of the Central Nervous System. Int. J. Mol. Sci. 2023, 24, 3048. https://doi.org/10.3390/ijms24033048

AMA Style

Mayo F, González-Vinceiro L, Hiraldo-González L, Calle-Castillejo C, Morales-Alvarez S, Ramírez-Lorca R, Echevarría M. Aquaporin-4 Expression Switches from White to Gray Matter Regions during Postnatal Development of the Central Nervous System. International Journal of Molecular Sciences. 2023; 24(3):3048. https://doi.org/10.3390/ijms24033048

Chicago/Turabian Style

Mayo, Francisco, Lourdes González-Vinceiro, Laura Hiraldo-González, Claudia Calle-Castillejo, Sara Morales-Alvarez, Reposo Ramírez-Lorca, and Miriam Echevarría. 2023. "Aquaporin-4 Expression Switches from White to Gray Matter Regions during Postnatal Development of the Central Nervous System" International Journal of Molecular Sciences 24, no. 3: 3048. https://doi.org/10.3390/ijms24033048

APA Style

Mayo, F., González-Vinceiro, L., Hiraldo-González, L., Calle-Castillejo, C., Morales-Alvarez, S., Ramírez-Lorca, R., & Echevarría, M. (2023). Aquaporin-4 Expression Switches from White to Gray Matter Regions during Postnatal Development of the Central Nervous System. International Journal of Molecular Sciences, 24(3), 3048. https://doi.org/10.3390/ijms24033048

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