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Article

A Genome-Wide Association Study Identified Novel Genetic Susceptibility Loci for Oral Cancer in Taiwan

by
Da-Tian Bau
1,2,3,
Ting-Yuan Liu
4,
Chia-Wen Tsai
1,2,
Wen-Shin Chang
1,2,
Jian Gu
5,
Jai-Sing Yang
4,
Liang-Chun Shih
1,2 and
Fuu-Jen Tsai
6,7,*
1
Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404333, Taiwan
2
Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung 404327, Taiwan
3
Department of Bioinformatics and Medical Engineering, Asia University, Taichung 41354, Taiwan
4
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan
5
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
6
Human Genetics Center, Department of Medical Research, China Medical University Hospital, Taichung 404327, Taiwan
7
Department of Medical Genetics, China Medical University Hospital, Taichung 404327, Taiwan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(3), 2789; https://doi.org/10.3390/ijms24032789
Submission received: 4 January 2023 / Revised: 26 January 2023 / Accepted: 30 January 2023 / Published: 1 February 2023
(This article belongs to the Special Issue State-of-the-Art Molecular Oncology in Taiwan)
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Abstract

Taiwan has the highest incidence rate of oral cancer in the world. Although oral cancer is mostly an environmentally induced cancer, genetic factors also play an important role in its etiology. Genome-wide association studies (GWAS) have identified nine susceptibility regions for oral cancers in populations of European descent. In this study, we performed the first GWAS of oral cancer in Taiwan with 1529 cases and 44,572 controls. We confirmed two previously reported loci on the 6p21.33 (HLA-B) and 6p21.32 (HLA-DQ gene cluster) loci, highlighting the importance of the human leukocyte antigen and, hence, the immunologic mechanisms in oral carcinogenesis. The TERT-CLMPT1L locus on 5p15.33, the 4q23 ADH1B locus, and the LAMC3 locus on 9q34.12 were also consistent in the Taiwanese. We found two new independent loci on 6p21.32, rs401775 in SKIV2L gene and rs9267798 in TNXB gene. We also found two suggestive novel Taiwanese-specific loci near the TPRS1 gene on 8q23.3 and in the TMED3 gene on 15q25.1. This study identified both common and unique oral cancer susceptibility loci in the Taiwanese as compared to populations of European descent and shed significant light on the etiology of oral cancer in Taiwan.
Keywords: oral cancer; genome-wide association study; SNP; HLA; TERT; TPRS1; TMED3 oral cancer; genome-wide association study; SNP; HLA; TERT; TPRS1; TMED3
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MDPI and ACS Style

Bau, D.-T.; Liu, T.-Y.; Tsai, C.-W.; Chang, W.-S.; Gu, J.; Yang, J.-S.; Shih, L.-C.; Tsai, F.-J. A Genome-Wide Association Study Identified Novel Genetic Susceptibility Loci for Oral Cancer in Taiwan. Int. J. Mol. Sci. 2023, 24, 2789. https://doi.org/10.3390/ijms24032789

AMA Style

Bau D-T, Liu T-Y, Tsai C-W, Chang W-S, Gu J, Yang J-S, Shih L-C, Tsai F-J. A Genome-Wide Association Study Identified Novel Genetic Susceptibility Loci for Oral Cancer in Taiwan. International Journal of Molecular Sciences. 2023; 24(3):2789. https://doi.org/10.3390/ijms24032789

Chicago/Turabian Style

Bau, Da-Tian, Ting-Yuan Liu, Chia-Wen Tsai, Wen-Shin Chang, Jian Gu, Jai-Sing Yang, Liang-Chun Shih, and Fuu-Jen Tsai. 2023. "A Genome-Wide Association Study Identified Novel Genetic Susceptibility Loci for Oral Cancer in Taiwan" International Journal of Molecular Sciences 24, no. 3: 2789. https://doi.org/10.3390/ijms24032789

APA Style

Bau, D.-T., Liu, T.-Y., Tsai, C.-W., Chang, W.-S., Gu, J., Yang, J.-S., Shih, L.-C., & Tsai, F.-J. (2023). A Genome-Wide Association Study Identified Novel Genetic Susceptibility Loci for Oral Cancer in Taiwan. International Journal of Molecular Sciences, 24(3), 2789. https://doi.org/10.3390/ijms24032789

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