Hypoxia and Intestinal Inflammation: Common Molecular Mechanisms and Signaling Pathways

Dvornikova, Kristina A.; Platonova, Olga N.; Bystrova, Elena Y.

doi:10.3390/ijms24032425

Open AccessReview

Hypoxia and Intestinal Inflammation: Common Molecular Mechanisms and Signaling Pathways

by

Kristina A. Dvornikova

,

Olga N. Platonova

and

Elena Y. Bystrova

^*

I.P. Pavlov Institute of Physiology RAS, 199034 St. Petersburg, Russia

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2023, 24(3), 2425; https://doi.org/10.3390/ijms24032425

Submission received: 14 December 2022 / Revised: 21 January 2023 / Accepted: 24 January 2023 / Published: 26 January 2023

(This article belongs to the Special Issue Molecular Mechanisms of Adaptation to Hypoxia 2.0)

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Abstract

The gastrointestinal tract (GI) has a unique oxygenation profile. It should be noted that the state of hypoxia can be characteristic of both normal and pathological conditions. Hypoxia-inducible factors (HIF) play a key role in mediating the response to hypoxia, and they are tightly regulated by a group of enzymes called HIF prolyl hydroxylases (PHD). In this review, we discuss the involvement of inflammation hypoxia and signaling pathways in the pathogenesis of inflammatory bowel disease (IBD) and elaborate in detail on the role of HIF in multiple immune reactions during intestinal inflammation. We emphasize the critical influence of tissue microenvironment and highlight the existence of overlapping functions and immune responses mediated by the same molecular mechanisms. Finally, we also provide an update on the development of corresponding therapeutic approaches that would be useful for treatment or prophylaxis of inflammatory bowel disease.

Keywords: hypoxia; HIF-1α; HIF-2α; innate immunity; adaptive immunity; inflammatory bowel disease; ulcerative colitis; Crohn’s disease; inflammation

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MDPI and ACS Style

Dvornikova, K.A.; Platonova, O.N.; Bystrova, E.Y. Hypoxia and Intestinal Inflammation: Common Molecular Mechanisms and Signaling Pathways. Int. J. Mol. Sci. 2023, 24, 2425. https://doi.org/10.3390/ijms24032425

AMA Style

Dvornikova KA, Platonova ON, Bystrova EY. Hypoxia and Intestinal Inflammation: Common Molecular Mechanisms and Signaling Pathways. International Journal of Molecular Sciences. 2023; 24(3):2425. https://doi.org/10.3390/ijms24032425

Chicago/Turabian Style

Dvornikova, Kristina A., Olga N. Platonova, and Elena Y. Bystrova. 2023. "Hypoxia and Intestinal Inflammation: Common Molecular Mechanisms and Signaling Pathways" International Journal of Molecular Sciences 24, no. 3: 2425. https://doi.org/10.3390/ijms24032425

APA Style

Dvornikova, K. A., Platonova, O. N., & Bystrova, E. Y. (2023). Hypoxia and Intestinal Inflammation: Common Molecular Mechanisms and Signaling Pathways. International Journal of Molecular Sciences, 24(3), 2425. https://doi.org/10.3390/ijms24032425

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Hypoxia and Intestinal Inflammation: Common Molecular Mechanisms and Signaling Pathways

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