Review Reports

Round 1

Reviewer 1 Report

I consider the subject of the manuscript entitled “Design and Synthesis of New Quinazolin-4-one Derivatives 2 with Negative mGlu7 Receptor Modulation Activity and Anti-3 psychotic-like Properties” to be of high interest and appropriate for publication in the International Journal of Molecular Sciences.

As a general observation, the manuscript is well structured and very well written. The synthesis and structural characterization of the compounds is clearly described and very thorough. As mental illness is an extremely important worldwide public health issue, I consider the search for new and potent antipsychotic agents to be very valuable.

Author Response

We are grateful for the positive opinion of our work.

Reviewer 2 Report

In this manuscript entitled Design and Synthesis of New Quinazolin-4-one Derivatives with Negative mGlu7 Receptor Modulation Activity and Anti-psychotic-like Properties), the authors have synthesized a series of Quinazolin-4-one Derivatives and screened their Anti-psychotic-like Properties. The result is interesting. However, to present a very high-impact work, the following revisions are suggested:

1.      Discussion regarding NMRs should be added briefly to the results and discussion section, specifically, splitting and spitting pattern

2.      For identification of prepared compounds, The IR spectra must be added

3.      I have noticed there is a difference (more than 1) in mass found compared to calculations so please check the whole compounds (A9-26, A9-27, A9-28, A9-29 ………etc)

4.      The optimization of Suzuki coupling reaction is needed, please refer to this ref (https://doi.org/10.1002/ejoc.201001497)

5.      R2 is the electron-donating group as shown good inhibition, Have the authors used the electron-withdrawing groups for improvement of activity?

 

6.      Make double check of references to be following the style of the journal

Author Response

Please see the attachment.

Author Response File: Author Response.pdf