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Article

Histopathological Gap in Aortic Diseases: A Prospective Analysis

by
Cosmin Marian Banceu
1,2,3,
Simona Gurzu
4,5,6,*,
Catalin-Bogdan Satala
4,
Dana Ghiga
7,
Mihai Halic Neamtu
8,9,
Vladimir Voth
10,
Markus Liebrich
10 and
Horatiu Suciu
2,3,6
1
I.O.S.U.D., George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania
2
Department of Surgery M3, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania
3
Emergency Institute for Cardiovascular Diseases and Transplantation Targu Mures, 540136 Targu Mures, Romania
4
Department of Pathology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania
5
Research Center for Oncopathology and Translational Medicine (CCOMT), George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania
6
Romanian Academy of Medical Sciences, 030167 Bucharest, Romania
7
Department of Medical Scientific Research Methodology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania
8
Swiss Federal Institute of Forest, Snow and Landscape Research WSL, 8903 Birmensdorf, Switzerland
9
Institute of Environmental Engineering, ETH Zurich, 8039 Zurich, Switzerland
10
Sana Cardiac Surgery, Herdweg 2, 70174 Stuttgart, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(20), 15470; https://doi.org/10.3390/ijms242015470
Submission received: 4 September 2023 / Revised: 8 October 2023 / Accepted: 16 October 2023 / Published: 23 October 2023
(This article belongs to the Special Issue Cardiovascular Diseases: Histopathological and Molecular Diagnostics)
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Abstract

Aortic dissection (AD) is a critical cardiovascular condition with the potential for devastating consequences. This study evaluated the histological changes in the aorta wall in patients with AD and aortic aneurysm (AA) who received surgical aortic replacement. Histopathological data showed that modifications of the media layer (p = 0.0197), myxomatous aspect (p = 0.0001), and subendothelial layer degeneration (p = 0.0107) were more frequently seen in AA versus AD samples. Patients with AA were approximately twice as likely to develop histological changes than those with AD (p = 0.0037). Patients with moderate or severe medial degeneration had a higher chance of developing AD (p = 0.0001). Because the histopathological score proved to be a predictor of both in-hospital and overall mortality, its evaluation should become the standard of care in any patients who undergo aortic replacement. Individualized postoperative management might be influenced by the histopathological aspect of the aortic layer.
Keywords: aortic dissection; aortic aneurysm; histology; surgical replacement; myxomatous aortic dissection; aortic aneurysm; histology; surgical replacement; myxomatous

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MDPI and ACS Style

Banceu, C.M.; Gurzu, S.; Satala, C.-B.; Ghiga, D.; Neamtu, M.H.; Voth, V.; Liebrich, M.; Suciu, H. Histopathological Gap in Aortic Diseases: A Prospective Analysis. Int. J. Mol. Sci. 2023, 24, 15470. https://doi.org/10.3390/ijms242015470

AMA Style

Banceu CM, Gurzu S, Satala C-B, Ghiga D, Neamtu MH, Voth V, Liebrich M, Suciu H. Histopathological Gap in Aortic Diseases: A Prospective Analysis. International Journal of Molecular Sciences. 2023; 24(20):15470. https://doi.org/10.3390/ijms242015470

Chicago/Turabian Style

Banceu, Cosmin Marian, Simona Gurzu, Catalin-Bogdan Satala, Dana Ghiga, Mihai Halic Neamtu, Vladimir Voth, Markus Liebrich, and Horatiu Suciu. 2023. "Histopathological Gap in Aortic Diseases: A Prospective Analysis" International Journal of Molecular Sciences 24, no. 20: 15470. https://doi.org/10.3390/ijms242015470

APA Style

Banceu, C. M., Gurzu, S., Satala, C.-B., Ghiga, D., Neamtu, M. H., Voth, V., Liebrich, M., & Suciu, H. (2023). Histopathological Gap in Aortic Diseases: A Prospective Analysis. International Journal of Molecular Sciences, 24(20), 15470. https://doi.org/10.3390/ijms242015470

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