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Volume 24
Issue 19
10.3390/ijms241914542
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Article

Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer

by
Margarida Coelho
1,2,3,4,
João Capela
5,
Sandra I. Anjo
1,2,3,
João Pacheco
5,
Margarida Sá Fernandes
5,
Isabel Amendoeira
5,6,7,
John G. Jones
1,2,3,
Luís Raposo
8,9 and
Bruno Manadas
1,2,3,*
1
CNC—Center for Neurosciences and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
2
CIBB—Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-517 Coimbra, Portugal
3
III Institute for Interdisciplinary Research, University of Coimbra (IIIUC), 3030-789 Coimbra, Portugal
4
Department of Chemistry, Faculty of Sciences and Technology, University of Coimbra, 3004-535 Coimbra, Portugal
5
Centro Hospitalar Universitário São João, 4200-319 Porto, Portugal
6
I3S, Instituto de Investigação e Inovação em Saúde, 4200-135 Porto, Portugal
7
Ipatimup, Instituto de Patologia e Imunologia Molecular da Universidade do Porto, 4200-465 Porto, Portugal
8
Portuguese Society of Endocrinology, Diabetes and Metabolism, 1600-892 Lisbon, Portugal
9
EPIUnit-Institute of Public Health, University of Porto, 4050-600 Porto, Portugal
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(19), 14542; https://doi.org/10.3390/ijms241914542
Submission received: 6 September 2023 / Revised: 20 September 2023 / Accepted: 22 September 2023 / Published: 26 September 2023
(This article belongs to the Collection Feature Papers in Molecular Oncology)
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Abstract

Differentiated thyroid cancer is the most common malignancy of the endocrine system. Although most thyroid nodules are benign, given the high incidence of thyroid nodules in the population, it is important to understand the differences between benign and malignant thyroid cancer and the molecular alterations associated with malignancy to improve detection and signal potential diagnostic, prognostic, and therapeutic targets. Proteomics analysis of benign and malignant human thyroid tissue largely revealed changes indicating modifications in RNA regulation, a common cancer characteristic. In addition, changes in the immune system and cell membrane/endocytic processes were also suggested to be involved. Annexin A1 was considered a potential malignancy biomarker and, similarly to other annexins, it was found to increase in the malignant group. Furthermore, a bioinformatics approach points to the transcription factor Sp1 as being potentially involved in most of the alterations seen in the malignant thyroid nodules.
Keywords: proteomics; screening; thyroid cancer; annexins; Sp1 proteomics; screening; thyroid cancer; annexins; Sp1

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MDPI and ACS Style

Coelho, M.; Capela, J.; Anjo, S.I.; Pacheco, J.; Fernandes, M.S.; Amendoeira, I.; Jones, J.G.; Raposo, L.; Manadas, B. Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer. Int. J. Mol. Sci. 2023, 24, 14542. https://doi.org/10.3390/ijms241914542

AMA Style

Coelho M, Capela J, Anjo SI, Pacheco J, Fernandes MS, Amendoeira I, Jones JG, Raposo L, Manadas B. Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer. International Journal of Molecular Sciences. 2023; 24(19):14542. https://doi.org/10.3390/ijms241914542

Chicago/Turabian Style

Coelho, Margarida, João Capela, Sandra I. Anjo, João Pacheco, Margarida Sá Fernandes, Isabel Amendoeira, John G. Jones, Luís Raposo, and Bruno Manadas. 2023. "Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer" International Journal of Molecular Sciences 24, no. 19: 14542. https://doi.org/10.3390/ijms241914542

APA Style

Coelho, M., Capela, J., Anjo, S. I., Pacheco, J., Fernandes, M. S., Amendoeira, I., Jones, J. G., Raposo, L., & Manadas, B. (2023). Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer. International Journal of Molecular Sciences, 24(19), 14542. https://doi.org/10.3390/ijms241914542

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