The Role of Autophagy and Apoptosis in Affected Skin and Lungs in Patients with Systemic Sclerosis
, Marina Andjelkovic †, Marina Parezanovic, Jovana Komazec, Milena Ugrin, Kristel Klaassen and Maja StojiljkovicRound 1
Reviewer 1 Report
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Author Response
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Reviewer 2 Report
The manuscript entitled "The role of autophagy and apoptosis in affected skin and lungs in patients with systemic sclerosis" brigs useful information regarding the pathophysiological mechanisms involved in apoptosis and autophagy processes associated with skin and lung lesions.
Observations:
Introduction
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Conclusions
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Author Response
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Reviewer 3 Report
The manuscript is a complete and updated review on the mechanisms of apoptosis and autophagy in systemic sclerosis. In particular the Authors report the role of dysregulated apoptosis and autophgy in the pathogenesis of skin and lung disease in systemic sclerosis patients. Finally, the Authors propose that elucidation of the molecular mechanisms underlying systemic sclerosis could lead to a molecular based and personalized therapy.
Author Response
We would like to thank to the reviewer for accepting our work for review.
