Regulation of PIN-FORMED Protein Degradation
Round 1
Reviewer 1 Report
The secondary transporters PIN-FORMED (PIN) proteins participate in the cell efflux of the plant signal chemical auxin. PIN genes serve a crucial role in controlling the asymmetric auxin distribution in a variety of developmental processes, such as embryogenesis, organogenesis, tissue differentiation, and tropic responses. PIN genes are only found in the genomes of multicellular plants. The authors of this review paper emphasized recent discoveries that add to our understanding of the regulation of PIN degradation, including vacuolar targeting, ubiquitin modification, vesicular trafficking, cytoskeletons, plant hormones, and environmental cues. Because of this, the current research is essential for controlling PIN-FORMED protein degradation pathways and has synthesized a number of data into a useful conclusion. The review is very well written, includes the majority of recent citations, and will be very beneficial to future studies on the regulation of PIN-FORMED protein breakdown. I must congratulate the authors of this research for choosing a pertinent subject and structuring and organizing it in a systematic way. I must thus suggest that this review paper be accepted for publication in the IJMS to the editor-in-chief.
Author Response
Thanks for your positive comments.
Reviewer 2 Report
This review aims to highlight our current understanding of the molecular mechanisms underlying PIN degradation pathways. The review is comprehensive and well-presented.
Minor comments:
Lane13: change “outstanding” to “important”
Lane 27: delete “a kind of”
Lane 91: Change “gravi-stimulation” to “gravistimulation”
Author Response
This review aims to highlight our current understanding of the molecular mechanisms underlying PIN degradation pathways. The review is comprehensive and well-presented.
Response: Thanks for your positive comments.
Minor comments:
Lane13: change “outstanding” to “important”
Response: The word is changed as suggested (Line 13).
Lane 27: delete “a kind of”
Response: The sentence is revised as suggested (Line 27).
Lane 91: Change “gravi-stimulation” to “gravistimulation”
Response: The word is changed as suggested (Line 91).
