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Review

Effects of Oleuropein and Hydroxytyrosol on Inflammatory Mediators: Consequences on Inflammaging

by
Fanny Pojero
1,
Anna Aiello
1,
Francesco Gervasi
2,
Calogero Caruso
1,
Mattia Emanuela Ligotti
1,
Anna Calabrò
1,
Antonio Procopio
3,
Giuseppina Candore
1,
Giulia Accardi
1,*,† and
Mario Allegra
4,†
1
Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Technologies, University of Palermo, 90134 Palermo, Italy
2
Specialistic Oncology Laboratory Unit, ARNAS Hospitals Civico Di Cristina e Benfratelli, 90127 Palermo, Italy
3
Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy
4
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, 90123 Palermo, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2023, 24(1), 380; https://doi.org/10.3390/ijms24010380
Submission received: 15 November 2022 / Revised: 14 December 2022 / Accepted: 21 December 2022 / Published: 26 December 2022
(This article belongs to the Special Issue The Role of Natural Products in Immunopharmacology)
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Abstract

Aging is associated with a low-grade, systemic inflammatory state defined as “inflammaging”, ruled by the loss of proper regulation of the immune system leading to the accumulation of pro-inflammatory mediators. Such a condition is closely connected to an increased risk of developing chronic diseases. A number of studies demonstrate that olive oil phenolic compound oleuropein and its derivative hydroxytyrosol contribute to modulating tissue inflammation and oxidative stress, thus becoming attractive potential candidates to be used in the context of nutraceutical interventions, in order to ameliorate systemic inflammation in aging subjects. In this review, we aim to summarize the available data about the anti-inflammatory properties of oleuropein and hydroxytyrosol, discussing them in the light of molecular pathways involved in the synthesis and release of inflammatory mediators in inflammaging.
Keywords: oleuropein; hydroxytyrosol; inflammaging; nutraceutical oleuropein; hydroxytyrosol; inflammaging; nutraceutical

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MDPI and ACS Style

Pojero, F.; Aiello, A.; Gervasi, F.; Caruso, C.; Ligotti, M.E.; Calabrò, A.; Procopio, A.; Candore, G.; Accardi, G.; Allegra, M. Effects of Oleuropein and Hydroxytyrosol on Inflammatory Mediators: Consequences on Inflammaging. Int. J. Mol. Sci. 2023, 24, 380. https://doi.org/10.3390/ijms24010380

AMA Style

Pojero F, Aiello A, Gervasi F, Caruso C, Ligotti ME, Calabrò A, Procopio A, Candore G, Accardi G, Allegra M. Effects of Oleuropein and Hydroxytyrosol on Inflammatory Mediators: Consequences on Inflammaging. International Journal of Molecular Sciences. 2023; 24(1):380. https://doi.org/10.3390/ijms24010380

Chicago/Turabian Style

Pojero, Fanny, Anna Aiello, Francesco Gervasi, Calogero Caruso, Mattia Emanuela Ligotti, Anna Calabrò, Antonio Procopio, Giuseppina Candore, Giulia Accardi, and Mario Allegra. 2023. "Effects of Oleuropein and Hydroxytyrosol on Inflammatory Mediators: Consequences on Inflammaging" International Journal of Molecular Sciences 24, no. 1: 380. https://doi.org/10.3390/ijms24010380

APA Style

Pojero, F., Aiello, A., Gervasi, F., Caruso, C., Ligotti, M. E., Calabrò, A., Procopio, A., Candore, G., Accardi, G., & Allegra, M. (2023). Effects of Oleuropein and Hydroxytyrosol on Inflammatory Mediators: Consequences on Inflammaging. International Journal of Molecular Sciences, 24(1), 380. https://doi.org/10.3390/ijms24010380

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