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Article

Probiotic Bifidobacterium longum subsp. longum Protects against Cigarette Smoke-Induced Inflammation in Mice

by
Kurtis F. Budden
1,
Shaan L. Gellatly
1,
Annalicia Vaughan
2,
Nadia Amorim
2,
Jay C. Horvat
1,
Nicole G. Hansbro
2,
David L. A. Wood
3,
Philip Hugenholtz
3,
Paul G. Dennis
4,
Peter A. B. Wark
1 and
Philip M. Hansbro
1,2,*
1
Priority Research Centre for Healthy Lungs and Immune Health Research Program, Hunter Medical Research Institute and The University of Newcastle, Callaghan, NSW 2308, Australia
2
Centre for Inflammation, School of Life Sciences, Faculty of Science, Centenary Institute and University of Technology Sydney, Sydney, NSW 2007, Australia
3
Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4102, Australia
4
School of Earth and Environmental Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(1), 252; https://doi.org/10.3390/ijms24010252
Submission received: 1 December 2022 / Revised: 18 December 2022 / Accepted: 20 December 2022 / Published: 23 December 2022
(This article belongs to the Special Issue Recent Advances and Future Perspective in Microbiota and Probiotics)
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Abstract

Bifidobacterium are prominent gut commensals that produce the short-chain fatty acid (SCFA) acetate, and they are often used as probiotics. Connections between the gut and the lung, termed the gut–lung axis, are regulated by the microbiome. The gut–lung axis is increasingly implicated in cigarette smoke-induced diseases, and cigarette smoke exposure has been associated with depletion of Bifidobacterium species. In this study, we assessed the impact of acetate-producing Bifidobacterium longum subsp. longum (WT) and a mutant strain with an impaired acetate production capacity (MUT) on cigarette smoke-induced inflammation. The mice were treated with WT or MUT B. longum subsp. longum and exposed to cigarette smoke for 8 weeks before assessments of lung inflammation, lung tissue gene expression and cecal SCFAs were performed. Both strains of B. longum subsp. longum reduced lung inflammation, inflammatory cytokine expression and adhesion factor expression and alleviated cigarette smoke-induced depletion in caecum butyrate. Thus, the probiotic administration of B. longum subsp. longum, irrespective of its acetate-producing capacity, alleviated cigarette smoke-induced inflammation and the depletion of cecal butyrate levels.
Keywords: probiotic; Bifidobacterium; cigarette smoke; COPD; inflammation; SCFA; acetate probiotic; Bifidobacterium; cigarette smoke; COPD; inflammation; SCFA; acetate

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MDPI and ACS Style

Budden, K.F.; Gellatly, S.L.; Vaughan, A.; Amorim, N.; Horvat, J.C.; Hansbro, N.G.; Wood, D.L.A.; Hugenholtz, P.; Dennis, P.G.; Wark, P.A.B.; et al. Probiotic Bifidobacterium longum subsp. longum Protects against Cigarette Smoke-Induced Inflammation in Mice. Int. J. Mol. Sci. 2023, 24, 252. https://doi.org/10.3390/ijms24010252

AMA Style

Budden KF, Gellatly SL, Vaughan A, Amorim N, Horvat JC, Hansbro NG, Wood DLA, Hugenholtz P, Dennis PG, Wark PAB, et al. Probiotic Bifidobacterium longum subsp. longum Protects against Cigarette Smoke-Induced Inflammation in Mice. International Journal of Molecular Sciences. 2023; 24(1):252. https://doi.org/10.3390/ijms24010252

Chicago/Turabian Style

Budden, Kurtis F., Shaan L. Gellatly, Annalicia Vaughan, Nadia Amorim, Jay C. Horvat, Nicole G. Hansbro, David L. A. Wood, Philip Hugenholtz, Paul G. Dennis, Peter A. B. Wark, and et al. 2023. "Probiotic Bifidobacterium longum subsp. longum Protects against Cigarette Smoke-Induced Inflammation in Mice" International Journal of Molecular Sciences 24, no. 1: 252. https://doi.org/10.3390/ijms24010252

APA Style

Budden, K. F., Gellatly, S. L., Vaughan, A., Amorim, N., Horvat, J. C., Hansbro, N. G., Wood, D. L. A., Hugenholtz, P., Dennis, P. G., Wark, P. A. B., & Hansbro, P. M. (2023). Probiotic Bifidobacterium longum subsp. longum Protects against Cigarette Smoke-Induced Inflammation in Mice. International Journal of Molecular Sciences, 24(1), 252. https://doi.org/10.3390/ijms24010252

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