Research on Graphene and Its Derivatives in Oral Disease Treatment
Abstract
:1. Introduction
2. Graphene-Based Materials
2.1. Graphene and Its Derivatives
2.2. Preparation of Graphene and Its Derivatives
2.3. Compatibility of Graphene-Based Materials
3. Improving the Physical and Chemical Performance of Dental Materials
4. Potential Application of Graphene-Based Materials in Oral Disease Treatment
4.1. Inhibiting Cariogenic Bacteria and Preventing Demineralization of Teeth
4.2. Control of Dental Pulp Infection and Promotion of hDPSC Differentiation
4.3. Suppressing Periodontal Bacteria and Facilitating Tissue Regeneration
4.4. Implant Coating and Improving Osseointegration
5. Perspective and Summary
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Main Subject | Form of Graphene Materials | Method | Material Type | Role and Advantages | Ref |
---|---|---|---|---|---|
Dental Materials (Restorative Dentistry) | Graphene–Ag nanoparticles (G–AgNp) Graphene oxide (GO) | Adding G–AgNp to a PMMA auto-polymerizing resin GO sheets were infused into primer | PMMA auto-polymerizing resin Primer | Antibacterial activity, minimal toxicity, improved flexural properties. Enhance shear bond strength | [68] [88] |
Endodontics | Graphene Oxide (GO) Graphene oxide (GO) | Nano-graphene oxide with antisense vicR RNA plasmid (GO–PEI–ASvicR). Graphene oxide (GO) adhesive | Plasmid Adhesive resin | Antibacterial (S. mutans) Shows comparable bond strength and durability of resin dentine bond. | [104] [87] |
Periodontics | Graphene | Graphene Quantum Dot coupled with curcumin (GQD–Cur) | Photosensitizing agents | Downregulation of the biofilm genes expression | [119] |
Implantology | Graphene oxide (GO) Graphene Reduced graphene oxide | Graphene oxide (GO) deposition (on a zirconia surface) Mg alloy with graphene nanoparticles (Gr) Reduced graphene oxide (rGO)-coated sandblasted | Direct-deposited graphene oxide on dental implants Coated on dental implants Coated on dental implants | Inhibited the attachment of S. mutans and stimulated proliferation and differentiation of osteoblasts. High cytocompatibility and superior osteogenic properties Accelerate the healing rate with the high potential of osseointegration. | [95] [88] [130] |
Tissue engineering | Graphene oxide (GO) | GO dental materials | A rat model of a non-critical mandibular defect. | Bone regeneration and biocompatibility | [70] |
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Liu, C.; Tan, D.; Chen, X.; Liao, J.; Wu, L. Research on Graphene and Its Derivatives in Oral Disease Treatment. Int. J. Mol. Sci. 2022, 23, 4737. https://doi.org/10.3390/ijms23094737
Liu C, Tan D, Chen X, Liao J, Wu L. Research on Graphene and Its Derivatives in Oral Disease Treatment. International Journal of Molecular Sciences. 2022; 23(9):4737. https://doi.org/10.3390/ijms23094737
Chicago/Turabian StyleLiu, Chengcheng, Dan Tan, Xiaoli Chen, Jinfeng Liao, and Leng Wu. 2022. "Research on Graphene and Its Derivatives in Oral Disease Treatment" International Journal of Molecular Sciences 23, no. 9: 4737. https://doi.org/10.3390/ijms23094737