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Article

Dendrobium nobile Lindley Administration Attenuates Atopic Dermatitis-like Lesions by Modulating Immune Cells

by
Sooyeon Hong
†,
Eun-Young Kim
†,
Seo-Eun Lim
,
Jae-Hyun Kim
,
Youngjoo Sohn
* and
Hyuk-Sang Jung
*
Department of Anatomy, College of Korean Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2022, 23(8), 4470; https://doi.org/10.3390/ijms23084470
Submission received: 20 February 2022 / Revised: 12 April 2022 / Accepted: 14 April 2022 / Published: 18 April 2022
(This article belongs to the Special Issue Biological Interactions of Bioactive Natural Products)
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Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease that can significantly affect daily life by causing sleep disturbance due to extreme itching. In addition, if the symptoms of AD are severe, it can cause mental disorders such as ADHD and suicidal ideation. Corticosteroid preparations used for general treatment have good effects, but their use is limited due to side effects. Therefore, it is essential to minimize the side effects and study effective treatment methods. Dendrobium nobile Lindley (DNL) has been widely used for various diseases, but to the best of our knowledge, its effect on AD has not yet been proven. In this study, the inhibitory effect of DNL on AD was confirmed in a DNCB-induced Balb/c mouse. In addition, the inhibitory efficacy of inflammatory cytokines in TNF-α/IFN-γ-induced HaCaT cells and PMACI-induced HMC-1 cells was confirmed. The results demonstrated that DNL decreased IgE, IL-6, IL-4, scratching behavior, SCORAD index, infiltration of mast cells and eosinophils and decreased the thickness of the skin. Additionally, DNL inhibited the expression of cytokines and inhibited the MAPK and NF-κB signaling pathways. This suggests that DNL inhibits cytokine expression, protein signaling pathway, and immune cells, thereby improving AD symptoms in mice.
Keywords: atopic dermatitis; IgE; IL-6; CD4; CD8; HaCaT; cytokine; TARC; GM-CSF; NF-κB atopic dermatitis; IgE; IL-6; CD4; CD8; HaCaT; cytokine; TARC; GM-CSF; NF-κB

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MDPI and ACS Style

Hong, S.; Kim, E.-Y.; Lim, S.-E.; Kim, J.-H.; Sohn, Y.; Jung, H.-S. Dendrobium nobile Lindley Administration Attenuates Atopic Dermatitis-like Lesions by Modulating Immune Cells. Int. J. Mol. Sci. 2022, 23, 4470. https://doi.org/10.3390/ijms23084470

AMA Style

Hong S, Kim E-Y, Lim S-E, Kim J-H, Sohn Y, Jung H-S. Dendrobium nobile Lindley Administration Attenuates Atopic Dermatitis-like Lesions by Modulating Immune Cells. International Journal of Molecular Sciences. 2022; 23(8):4470. https://doi.org/10.3390/ijms23084470

Chicago/Turabian Style

Hong, Sooyeon, Eun-Young Kim, Seo-Eun Lim, Jae-Hyun Kim, Youngjoo Sohn, and Hyuk-Sang Jung. 2022. "Dendrobium nobile Lindley Administration Attenuates Atopic Dermatitis-like Lesions by Modulating Immune Cells" International Journal of Molecular Sciences 23, no. 8: 4470. https://doi.org/10.3390/ijms23084470

APA Style

Hong, S., Kim, E.-Y., Lim, S.-E., Kim, J.-H., Sohn, Y., & Jung, H.-S. (2022). Dendrobium nobile Lindley Administration Attenuates Atopic Dermatitis-like Lesions by Modulating Immune Cells. International Journal of Molecular Sciences, 23(8), 4470. https://doi.org/10.3390/ijms23084470

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