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Review

Role and Regulation of Pif1 Family Helicases at the Replication Fork

1
Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
2
Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Yves Henry
Int. J. Mol. Sci. 2022, 23(7), 3736; https://doi.org/10.3390/ijms23073736
Received: 28 February 2022 / Revised: 24 March 2022 / Accepted: 25 March 2022 / Published: 29 March 2022
(This article belongs to the Special Issue Mechanisms of DNA Replication Fork Progression, Stalling, and Rescue)
Pif1 helicases are a multifunctional family of DNA helicases that are important for many aspects of genomic stability in the nucleus and mitochondria. Pif1 helicases are conserved from bacteria to humans. Pif1 helicases play multiple roles at the replication fork, including promoting replication through many barriers such as G-quadruplex DNA, the rDNA replication fork barrier, tRNA genes, and R-loops. Pif1 helicases also regulate telomerase and promote replication termination, Okazaki fragment maturation, and break-induced replication. This review highlights many of the roles and regulations of Pif1 at the replication fork that promote cellular health and viability. View Full-Text
Keywords: Pif1 helicase; DNA helicase; replication fork; replication fork barriers; G-quadruplexes; telomerase Pif1 helicase; DNA helicase; replication fork; replication fork barriers; G-quadruplexes; telomerase
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MDPI and ACS Style

Malone, E.G.; Thompson, M.D.; Byrd, A.K. Role and Regulation of Pif1 Family Helicases at the Replication Fork. Int. J. Mol. Sci. 2022, 23, 3736. https://doi.org/10.3390/ijms23073736

AMA Style

Malone EG, Thompson MD, Byrd AK. Role and Regulation of Pif1 Family Helicases at the Replication Fork. International Journal of Molecular Sciences. 2022; 23(7):3736. https://doi.org/10.3390/ijms23073736

Chicago/Turabian Style

Malone, Emory G., Matthew D. Thompson, and Alicia K. Byrd. 2022. "Role and Regulation of Pif1 Family Helicases at the Replication Fork" International Journal of Molecular Sciences 23, no. 7: 3736. https://doi.org/10.3390/ijms23073736

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