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Prion Protein: The Molecule of Many Forms and Faces

Centre for Immunology and Development, Blood Transfusion Centre of Slovenia, Šlajmerjeva 6, SI-1000 Ljubljana, Slovenia
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Academic Editor: Holger Wille
Int. J. Mol. Sci. 2022, 23(3), 1232; https://doi.org/10.3390/ijms23031232
Received: 2 December 2021 / Revised: 10 January 2022 / Accepted: 21 January 2022 / Published: 22 January 2022
(This article belongs to the Special Issue Axonopathy in Neurodegenerative Diseases)
Cellular prion protein (PrPC) is a glycosylphosphatidylinositol (GPI)-anchored protein most abundantly found in the outer membrane of neurons. Due to structural characteristics (a flexible tail and structured core), PrPC interacts with a wide range of partners. Although PrPC has been proposed to be involved in many physiological functions, only peripheral nerve myelination homeostasis has been confirmed as a bona fide function thus far. PrPC misfolding causes prion diseases and PrPC has been shown to mediate β-rich oligomer-induced neurotoxicity in Alzheimer’s and Parkinson’s disease as well as neuroprotection in ischemia. Upon proteolytic cleavage, PrPC is transformed into released and attached forms of PrP that can, depending on the contained structural characteristics of PrPC, display protective or toxic properties. In this review, we will outline prion protein and prion protein fragment properties as well as overview their involvement with interacting partners and signal pathways in myelination, neuroprotection and neurodegenerative diseases. View Full-Text
Keywords: prion protein; prion protein fragments; neuroprotection; myelination; ischemic stroke; neurodegenerative disease prion protein; prion protein fragments; neuroprotection; myelination; ischemic stroke; neurodegenerative disease
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MDPI and ACS Style

Kovač, V.; Čurin Šerbec, V. Prion Protein: The Molecule of Many Forms and Faces. Int. J. Mol. Sci. 2022, 23, 1232. https://doi.org/10.3390/ijms23031232

AMA Style

Kovač V, Čurin Šerbec V. Prion Protein: The Molecule of Many Forms and Faces. International Journal of Molecular Sciences. 2022; 23(3):1232. https://doi.org/10.3390/ijms23031232

Chicago/Turabian Style

Kovač, Valerija, and Vladka Čurin Šerbec. 2022. "Prion Protein: The Molecule of Many Forms and Faces" International Journal of Molecular Sciences 23, no. 3: 1232. https://doi.org/10.3390/ijms23031232

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